ArticleMolecular biology of the cell2015
Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy.EMBO reports · 2024Article
- Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage.Nature communications · 2024Article
- Short-term molecular consequences of chromosome mis-segregation for genome stability.Nature communications · 2023Article
- The Dynamic Instability of the Aneuploid Genome.Frontiers in cell and developmental biology · 2022Review
- Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity.Frontiers in immunology · 2022Review
- Checkpoint Responses to DNA Double-Strand Breaks.Annual review of biochemistry · 2020Review
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- Article
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- Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro.Nature communications · 2018Article
- FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.Nature communications · 2018Article
- Cellular Stress Associated with Aneuploidy.Developmental cell · 2018Review
- Chromosome passenger complex is required for the survival of cells with ring chromosomes in fission yeast.PloS one · 2018Article
- Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.Cancer research · 2017Article
- Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.Developmental cell · 2017Article
- Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts.Applied and environmental microbiology · 2017Review
- Aneuploidy Causes Non-genetic Individuality.Cell · 2017Article
- Single-chromosome Gains Commonly Function as Tumor Suppressors.Cancer cell · 2017Article
- Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature.Oncotarget · 2016Article
- Too much to handle - how gaining chromosomes destabilizes the genome.Cell cycle (Georgetown, Tex.) · 2016Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic instability is a hallmark of aneuploidy in budding and fission yeast. All aneuploid yeast strains analyzed to date harbor elevated levels of Rad52-GFP foci, a sign of DNA damage. Here we investigate how continuously elevated levels of DNA damage affect aneuploid cells. We show that Rad52-GFP foci form during S phase, consistent with the observation that DNA replication initiation and elongation are impaired in some aneuploid yeast strains. We furthermore find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequences. Many aneuploid yeast strains adapt to DNA damage and undergo mitosis despite the presence of unrepaired DNA leading to cell death. Wild-type cells exposed to low levels of DNA damage exhibit a similar phenotype, indicating that adaptation to low levels of unrepaired DNA is a general property of the cell's response to DNA damage. Our results indicate that by causing low levels of DNA damage, whole-chromosome aneuploidies lead to DNA breaks that persist into mitosis. Such breaks provide the substrate for translocations and deletions that are a hallmark of cancer.
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