ArticleArchives of toxicology2015
Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.
Article in Archives of toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pesticide exposure and the development of Parkinson disease: a systematic review of Brazilian studies.Cadernos de saude publica · 2025Pooled it
- The SH-SY5Y cell line in Parkinson's disease research: a systematic review.Molecular neurodegeneration · 2017Pooled it
- A dual-function host-guest antioxidant system for synergistic treatment of diquat poisoning.RSC advances · 2026Article
- Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning.iScience · 2025Article
- Protective impacts of bamboo leaf flavonoids in stressed broilers induced by diquat: Insight of antioxidant, immune response and intestinal barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies.Frontiers in pharmacology · 2025Review
- Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat.Molecular neurobiology · 2024Review
- Selenomethionine and Allicin Synergistically Mitigate Intestinal Oxidative Injury by Activating the Nrf2 Pathway.Toxics · 2024Article
- Article
- Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice.The American journal of pathology · 2023Article
- Analysis of Human microRNA Expression Profiling During Diquat-Induced Renal Proximal Tubular Epithelial Cell Injury.Journal of inflammation research · 2023Article
- Aluminum Induced Necroptosis of PC12 Cells via TNFR1-RIP1/RIP3 Signalling Pathway.Neurochemical research · 2022Article
- In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach.Environmental science and pollution research international · 2021Article
- Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury.Applied microbiology and biotechnology · 2021Article
- Vitamin DOxidative medicine and cellular longevity · 2021Article
- Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat.Animals : an open access journal from MDPI · 2020Article
- Taurine Alleviates Intestinal Injury by Mediating Tight Junction Barriers in Diquat-Challenged Piglet Models.Frontiers in physiology · 2020Article
- Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.Journal of animal science and biotechnology · 2020Article
- SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.BMC neuroscience · 2017Article
- Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.Parkinson's disease · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Evidence indicates that Parkinson's disease (PD), in addition to having a genetic aetiology, has an environmental component that contributes to disease onset and progression. The exact nature of any environmental agent contributing to PD is unknown in most cases. Given its similarity to paraquat, an agrochemical removed from registration in the EU for its suspected potential to cause PD, we have investigated the in vitro capacity of the related herbicide Diquat to cause PD-like cell death. Diquat showed greater toxicity towards SH-SY5Y neuroblastoma cells and human midbrain neural cells than paraquat and also MPTP, which was independent of dopamine transporter-mediated uptake. Diquat caused cell death independently of caspase activation, potentially via RIP1 kinase, with only a minor contribution from apoptosis, which was accompanied by enhanced reactive oxygen species production in the absence of major inhibition of complex I of the mitochondrial respiratory chain. No changes in α-synuclein expression were observed following 24-h or 4-week exposure. Diquat may, therefore, kill neural tissue by programmed necrosis rather than apoptosis, reflecting the pathological changes seen following high-level exposure, although its ability to promote PD is unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.