ArticleHypertension research : official journal of the Japanese Society of Hypertension2015
Iron restriction inhibits renal injury in aldosterone/salt-induced hypertensive mice.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 17 citations in OpenAlex.
- Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review).Molecular medicine reports · 2026Review
- The Regulatory Landscape of Ferroptosis and Iron Homeostasis: Pathophysiological Mechanisms and Therapeutic Horizons in Cardiovascular Disease.Drug design, development and therapy · 2026Review
- Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor-Associated Hypertension.Journal of the American Heart Association · 2024Article
- Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Role of Iron-Related Oxidative Stress and Mitochondrial Dysfunction in Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2022Review
- Iron in Cardiovascular Disease: Challenges and Potentials.Frontiers in cardiovascular medicine · 2021Review
- Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats.Heart and vessels · 2018Article
- Attenuation of hypertension and renal damage in renovascular hypertensive rats by iron restriction.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Novel insights into renovascular hypertension and cardio-renal protection by iron restriction.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Aldosterone induces NRK-52E cell apoptosis in acute kidney injury via rno-miR-203 hypermethylation and Kim-1 upregulation.Experimental and therapeutic medicine · 2016Article
- Increased Dietary Salt Intake Does Not Influence Influenza A Virus-Induced Disease Severity in Mice.Viral immunology · 2015Article
- The Central Role of Neutrophil Gelatinase-Associated Lipocalin in Cardiovascular Fibrosis.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Possible therapeutic impact of the iron chelation on renal fibrosis.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
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9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Excess iron is associated with the pathogenesis of several renal diseases. Aldosterone is reported to have deleterious effects on the kidney, but there have been no reports of the role of iron in aldosterone/salt-induced renal injury. Therefore, we investigated the effects of dietary iron restriction on the development of hypertension and renal injury in aldosterone/salt-induced hypertensive mice. Ten-week-old male C57BL/6J mice were uninephrectomized and infused with aldosterone for four weeks. These were divided into two groups: one fed a high-salt diet (Aldo) and the other fed a high-salt with iron-restricted diet (Aldo-IR). Vehicle-infused mice without a uninephrectomy were also divided into two groups: one fed a normal diet (control) and the other fed an iron-restricted diet (IR) for 4 weeks. As compared with control and IR mice, Aldo mice showed an increase in both systolic blood pressure and urinary albumin/creatinine ratio, but these increases were reduced in the Aldo-IR group. In addition, renal histology revealed that Aldo mice exhibited glomerulosclerosis and tubulointerstitial fibrosis, whereas these changes were attenuated in Aldo-IR mice. Expression of intracellular iron transport protein transferrin receptor 1 was increased in the renal tubules of Aldo mice compared with control mice. Dietary iron restriction attenuated the development of hypertension and renal injury in aldosterone/salt-induced hypertensive mice.
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