ArticleMolecular & cellular proteomics : MCP2015
Discovery of predictive biomarkers for litter size in boar spermatozoa.
Article in Molecular & cellular proteomics : MCP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 109 citations in OpenAlex.
- Capacitation-Induced Zinc Ion Flux and Sperm Plasma Membrane Remodeling Predict Porcine In Vitro Fertilization Cleavage Success.Molecular reproduction and development · 2026Article
- Biomarkers of sperm fertility in pigs: a relevant tool for the discrimination of sub‑fertile males?Animal reproduction · 2026Article
- Investigating the correlation of glucose-regulated protein 78 with sperm motility and kinematic parameters insights into male fertility.Journal of animal science and technology · 2026Article
- Pilot evaluation of sperm mobility for boar fertility classification using machine learning.Translational animal science · 2026Article
- Nicotinamide Mononucleotide Enhances Boar Sperm Quality via Maintaining Mitochondrial Function During Liquid Storage.Animals : an open access journal from MDPI · 2025Article
- Does the Type of Semen Affect the Phosphoproteome of Turkey (International journal of molecular sciences · 2025Article
- Proteostasis as a Sentry for Sperm Quality and Male Fertility.Advances in experimental medicine and biology · 2025Review
- Proteomic and functional analysis of alpaca (Frontiers in veterinary science · 2025Article
- The Equilibrium of Bacterial Microecosystem: Probiotics, Pathogenic Bacteria, and Natural Antimicrobial Substances in Semen.Microorganisms · 2024Review
- Biomarker-based human and animal sperm phenotyping: the good, the bad and the ugly†.Biology of reproduction · 2024Review
- Age-dependent variations in proteomic characteristics of spermatozoa in Simmental bull.Frontiers in veterinary science · 2024Article
- Cryopreservation Induces Acetylation of Metabolism-Related Proteins in Boar Sperm.International journal of molecular sciences · 2023Article
- Pharmacological Evidence Suggests That Slo3 Channel Is the Principal KInternational journal of molecular sciences · 2023Article
- Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility.Journal of animal science and biotechnology · 2023Article
- Hexane fraction ofHeliyon · 2023Article
- Prediction of male fertility using Ras-related proteins.Journal of animal science and technology · 2022Article
- Establishment of a male fertility prediction model with sperm RNA markers in pigs as a translational animal model.Journal of animal science and biotechnology · 2022Article
- Heat shock protein family D member 1 in boar spermatozoa is strongly related to the litter size of inseminated sows.Journal of animal science and biotechnology · 2022Article
- Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Proteomic Analysis of Hypothalamus and Pituitary Gland in Pre and Postpubertal Brahman Heifers.Frontiers in genetics · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional semen analysis has been used for prognosis and diagnosis of male fertility. Although this tool is essential for providing initial quantitative information about semen, it remains a subject of debate. Therefore, development of new methods for the prognosis and diagnosis of male fertility should be seriously considered for animal species of economic importance as well as for humans. In the present study, we applied a comprehensive proteomic approach to identify global protein biomarkers in boar spermatozoa in order to increase the precision of male fertility prognoses and diagnoses. We determined that l-amino acid oxidase, mitochondrial malate dehydrogenase 2, NAD (MDH2), cytosolic 5'-nucleotidase 1B, lysozyme-like protein 4, and calmodulin (CALM) were significantly and abundantly expressed in high-litter size spermatozoa. We also found that equatorin, spermadhesin AWN, triosephosphate isomerase (TPI), Ras-related protein Rab-2A (RAB2A), spermadhesin AQN-3, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUFS2) were significantly and abundantly expressed in low-litter size spermatozoa (>3-fold). Moreover, RAB2A, TPI, and NDUFS2 were negatively correlated with litter size, whereas CALM and MDH2 were positively correlated. This study provides novel biomarkers for the prediction of male fertility. To the best of our knowledge, this is the first work that shows significantly increased litter size using male fertility biomarkers in a field trial. Moreover, these protein markers may provide new developmental tools for the selection of superior sires as well as for the prognosis and diagnosis of male fertility.
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