ArticleJournal of materials science. Materials in medicine2015
Silver-containing antimicrobial membrane based on chitosan-TPP hydrogel for the treatment of wounds.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Glycosylated-Chitosan Derivatives: A Systematic Review.Molecules (Basel, Switzerland) · 2020Pooled it
- A Scoping Review of Recent Developments in Cellulose-Derived Hydrogels for Dental Applications.Pharmaceutics · 2025Review
- Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Advancements and Challenges of Nanostructured Lipid Carriers for Wound Healing Applications.International journal of nanomedicine · 2024Review
- Article
- Golden and Silver-Golden Chitosan Hydrogels and Fabrics Modified with Golden Chitosan Hydrogels.International journal of molecular sciences · 2022Article
- Silver Nanoparticles and Their Antibacterial Applications.International journal of molecular sciences · 2021Review
- Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control.Marine drugs · 2021Article
- Ionotropic Gelation of Chitosan Flat Structures and Potential Applications.Molecules (Basel, Switzerland) · 2021Review
- Supercritical Phase Inversion: A Powerful Tool for Generating Cellulose Acetate-AgNOMaterials (Basel, Switzerland) · 2020Article
- Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives.Gels (Basel, Switzerland) · 2018Review
- A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing.RSC advances · 2018Review
- Alginate membranes loaded with hyaluronic acid and silver nanoparticles to foster tissue healing and to control bacterial contamination of non-healing wounds.Journal of materials science. Materials in medicine · 2018Article
- [Research progress on the animal models and treatment strategies of diabetic foot ulcer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Review
- Silver nanoparticles as potential antibacterial agents.Molecules (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of non-healing wounds represents hitherto a severe dilemma because of their failure to heal caused by repeated tissue insults, bacteria contamination and altered physiological condition. This leads to face huge costs for the healthcare worldwide. To this end, the development of innovative biomaterials capable of preventing bacterial infection, of draining exudates and of favoring wound healing is very challenging. In this study, we exploit a novel technique based on the slow diffusion of tripolyphosphate for the preparation of macroscopic chitosan hydrogels to obtain soft pliable membranes which include antimicrobial silver nanoparticles (AgNPs) stabilized by a lactose-modified chitosan (Chitlac). UV-Vis and TEM analyses demonstrated the time stability and the uniform distribution of AgNPs in the gelling mixture, while swelling studies indicated the hydrophilic behavior of membrane. A thorough investigation on bactericidal properties of the material pointed out the synergistic activity of chitosan and AgNPs to reduce the growth of S. aureus, E. coli, S. epidermidis, P. aeruginosa strains and to break apart mature biofilms. Finally, biocompatibility assays on keratinocytes and fibroblasts did not prove any harmful effects on the viability of cells. This novel technique enables the production of bioactive membranes with great potential for the treatment of non-healing wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.