ReviewAnnals of the New York Academy of Sciences2015
The biology of Plasmodium vivax explored through genomics.
Review in Annals of the New York Academy of Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Plasmodium vivax populations in the western Greater Mekong Subregion evaluated using a genetic barcode.PLoS neglected tropical diseases · 2024Article
- Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.Science advances · 2024Article
- Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms.PLoS neglected tropical diseases · 2024Article
- Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas.Scientific reports · 2023Article
- Plasmodium vivax: the potential obstacles it presents to malaria elimination and eradication.Tropical diseases, travel medicine and vaccines · 2022Review
- In vitro models for human malaria: targeting the liver stage.Trends in parasitology · 2022Review
- Non-Human Primate Malaria Infections: A Review on the Epidemiology in Malaysia.International journal of environmental research and public health · 2022Review
- GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.Nucleic acids research · 2022Article
- Review
- Zoonotic Malaria: Non-Pathogens (Basel, Switzerland) · 2021Review
- Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil.PLoS neglected tropical diseases · 2020Article
- Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.PLoS neglected tropical diseases · 2020Article
- Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea.The Korean journal of parasitology · 2018Review
- Malaria Elimination: Time to Target All Species.The American journal of tropical medicine and hygiene · 2018Review
- Review
- Genome-wide diversity and differentiation in New World populations of the human malaria parasite Plasmodium vivax.PLoS neglected tropical diseases · 2017Article
- Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45.Malaria journal · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Malaria is a mosquito-borne disease caused by the Plasmodium parasite. Of the four Plasmodium species that routinely cause human malaria, Plasmodium vivax is the most widespread species outside Africa, causing ∼18.9 million cases in 2012. P. vivax cannot be cultured continuously in vitro, which severely hampers research in nonendemic and endemic countries alike. Consequently, whole-genome sequencing has become an effective means to interrogate the biology of the P. vivax parasite. Our comparative genomic analysis of five P. vivax reference genomes and several whole-genome sequences of the closely related monkey malaria species P. cynomolgi has revealed an extraordinary level of genetic diversity and enabled characterization of novel multigene families and important single-copy genes. The generation of whole-genome sequences from multiple clinical isolates is also driving forward knowledge concerning the biology and evolution of the species. Understanding the biology of P. vivax is crucial to develop potential antimalarial drugs and vaccines and to achieve the goal of eliminating malaria.
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Registered trials
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