Evidence map›Paper›PMID 25693199›Full record

ArticlePloS one2015

Microstructural white matter tissue characteristics are modulated by homocysteine: a diffusion tensor imaging study.

Jung-Lung Hsu, Wei-Hung Chen, Chyi-Huey Bai, Jyu-Gang Leu, Chien-Yeh Hsu, Max A Viergever, Alexander Leemans

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jung-Lung HsuGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Section of Dementia and Cognitive Impairment, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Wei-Hung ChenDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chyi-Huey BaiDepartment of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Jyu-Gang LeuCollege of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Chien-Yeh HsuGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Max A ViergeverImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Taipei Medical University · TWUniversity Medical Center Utrecht · NLFu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homocysteine level can lead to adverse effects on the brain white matter through endothelial dysfunction, microstructural inflammation, and neurotoxin effects. Despite previously observed associations between elevated homocysteine and macroscopic structural brain changes, it is still unknown whether microstructural associations of homocysteine on brain tissue properties can be observed in healthy subjects with routine MRI. To this end, we investigated potential relationships between homocysteine levels and microstructural measures computed with diffusion tensor imaging (DTI) in a cohort of 338 healthy participants. Significant positive correlations were observed between homocysteine levels and diffusivity measures in the bilateral temporal WM, the brainstem, and the bilateral cerebellar peduncle. This is the first study demonstrating that DTI is sufficiently sensitive to relate microstructural WM properties to homocysteine levels in healthy subjects.

Indexed as

Diffusion Tensor ImagingAdultAgedAged, 80 and overFemaleHomocysteineHumansImage Processing, Computer-AssistedMaleMiddle AgedRisk FactorsWhite MatterHomocysteine

Identifiers

PMID25693199
PMCPMC4334653
OpenAlexW1984951047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.