ArticlePloS one2015
Bovine milk proteome in the first 9 days: protein interactions in maturation of the immune and digestive system of the newborn.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 117 citations in OpenAlex.
- Trial
- Pilot-scale ultraviolet-C and nano-second pulsed electric field processing of milk: Microbial inactivation and preservation of serum proteins.Current research in food science · 2026Article
- Characterization and Comparison of Milk Fat Globule Membrane Proteins, Whey Protein Concentrate, and Micellar Casein Concentrate.Food science & nutrition · 2026Article
- Breastfeeding and infant gut microbiota: influence of bioactive components.Gut microbes · 2025Review
- Influence of different processing methods on anti-trypsin activity in bovine colostrum.JDS communications · 2025Article
- The skimmed milk proteome of dairy cows is affected by the stage of lactation and by supplementation with polyunsaturated fatty acids.Scientific reports · 2024Article
- Article
- Evaluation of the differences in proteomics of high-quality bovine colostrum and low-quality bovine colostrum.Veterinary medicine and science · 2023Article
- Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control.Veterinary sciences · 2023Article
- Distinguishing Natural Infections of the Bovine Mammary Gland byAnimals : an open access journal from MDPI · 2023Article
- Changes in Whey Proteome between Mediterranean and Murrah Buffalo Colostrum and Mature Milk Reflect Their Pharmaceutical and Medicinal Value.Molecules (Basel, Switzerland) · 2022Article
- Parity of Calving Influences the Likelihood of Calves HavingVeterinary medicine international · 2022Article
- Heat Stress: Effects on Rumen Microbes and Host Physiology, and Strategies to Alleviate the Negative Impacts on Lactating Dairy Cows.Frontiers in microbiology · 2022Review
- Biomarkers in a socially exchanged /fluid reflect colony maturity, behavior, and distributed metabolism.eLife · 2021Article
- Current Diagnostic Methods for Assessing Transfer of Passive Immunity in Calves and Possible Improvements: A Literature Review.Animals : an open access journal from MDPI · 2021Review
- Performance and microbiota of the digestive tract of Nellore calves supplemented with fungi isolated from bovine rumen.Veterinary world · 2021Article
- MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker.Animals : an open access journal from MDPI · 2020Review
- Lipoproteins Contribute to the Anti-inflammatory Capacity ofFrontiers in microbiology · 2020Article
- Milk proteome from in silico data aggregation allows the identification of putative biomarkers of negative energy balance in dairy cows.Scientific reports · 2019Article
- Transcriptional profiling of swine mammary gland during the transition from colostrogenesis to lactogenesis using RNA sequencing.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to better understand the milk proteome and its changes from colostrum to mature milk, samples taken at seven time points in the first 9 days from 4 individual cows were analyzed using proteomic techniques. Both the similarity in changes from day 0 to day 9 in the quantitative milk proteome, and the differences in specific protein abundance, were observed among four cows. One third of the quantified proteins showed a significant decrease in concentration over the first 9 days after calving, especially in the immune proteins (as much as 40 fold). Three relative high abundant enzymes (XDH, LPL, and RNASE1) and cell division and proliferation protein (CREG1) may be involved in the maturation of the gastro-intestinal tract. In addition, high correlations between proteins involved in complement and blood coagulation cascades illustrates the complex nature of biological interrelationships between milk proteins. The linear decrease of protease inhibitors and proteins involved in innate and adaptive immune system implies a protective role for protease inhibitor against degradation. In conclusion, the results found in this study not only improve our understanding of the role of colostrum in both host defense and development of the newborn calf but also provides guidance for the improvement of infant formula through better understanding of the complex interactions between milk proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.