ArticlePLoS neglected tropical diseases2015
The spatiotemporal expansion of human rabies and its probable explanation in mainland China, 2004-2013.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Safety, immunogenicity of lyophilized purified vero cell cultured rabies vaccine administered in Zagreb and Essen regimen in post-exposure subjects: A post-marketing, parallel control clinical trial.Human vaccines & immunotherapeutics · 2021Trial
- Simulating rabies post-exposure prophylaxis among patients with human immunodeficiency virus infection using a six-dose Essen regimen administrated with human diploid cell vaccine: A single-arm pilot study in Chinese population.Human vaccines & immunotherapeutics · 2025Article
- Spatiotemporal Distribution of Human Rabies and Identification of Predominant Risk Factors in China from 2004 to 2020.PLoS neglected tropical diseases · 2024Article
- Influencing factors and prediction of neutralizing antibodies in post-exposure rabies vaccine recipients.Heliyon · 2024Article
- Factors associated with the spatiotemporal distribution of dog rabies in Tunisia.PLoS neglected tropical diseases · 2024Article
- Model misspecification misleads inference of the spatial dynamics of disease outbreaks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ecological and Socioeconomic Factors in the Occurrence of Rabies: A Forgotten Scenario.Infectious disease reports · 2022Article
- Clinical, epidemiological, and spatial features of human rabies cases in Metro Manila, the Philippines from 2006 to 2015.PLoS neglected tropical diseases · 2022Article
- Epidemiological and numerical simulation of rabies spreading from canines to various human populations in mainland China.PLoS neglected tropical diseases · 2021Article
- Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review.PLoS neglected tropical diseases · 2021Article
- A cointegration analysis of rabies cases and weather components in Davao City, Philippines from 2006 to 2017.PloS one · 2020Article
- Post-exposure prophylaxis vaccination rate and risk factors of human rabies in mainland China: a meta-analysis.Epidemiology and infection · 2018Article
- Transmission dynamics of re-emerging rabies in domestic dogs of rural China.PLoS pathogens · 2018Article
- The role of socioeconomic and climatic factors in the spatio-temporal variation of human rabies in China.BMC infectious diseases · 2018Article
- Spatiotemporal analysis of canine rabies in El Salvador: Violence and poverty as social factors of canine rabies.PloS one · 2018Article
- Article
- Assessing the Risk of a Canine Rabies Incursion in Northern Australia.Frontiers in veterinary science · 2017Article
- Probable Rabies Virus Transmission through Organ Transplantation, China, 2015.Emerging infectious diseases · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHuman rabies is a significant public health concern in mainland China. However, the neglect of rabies expansion and scarce analyses of the dynamics have made the spatiotemporal spread pattern of human rabies and its determinants being poorly understood.
methodsWe collected geographic locations and timeline of reported human rabies cases, rabies sequences and socioeconomic variables for the years 2004-2013, and integrated multidisciplinary approaches, including epidemiological characterization, hotspots identification, risk factors analysis and phylogeographic inference, to explore the spread pattern of human rabies in mainland China during the last decade.
resultsThe results show that human rabies distribution and hotspots were expanding from southeastern regions to north or west regions, which could be associated with the evolution of the virus, especially the clade I-G. A Panel Poisson Regression analysis reveals that human rabies incidences had significant correlation with the education level, GDP per capita, temperature at one-month lag and canine rabies outbreak at two-month lag.
conclusionsThe reduction in the overall human rabies incidence was accompanied by a westward and northward expansion of the circulating region in mainland China. Higher risk of human rabies was associated with lower level of education and economic status. New clades of rabies, especial Clade I-G, played an important role in recent spread. Our findings provide valuable information for rabies control and prevention in the future.
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