ArticlePLoS computational biology2015
Heterogeneous CD8+ T cell migration in the lymph node in the absence of inflammation revealed by quantitative migration analysis.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Genetically inducible coordinators of cytokine signaling pathways for interrogating T cell motility.bioRxiv : the preprint server for biology · 2026Article
- Anisotropic persistent random walk model simulates T-cells migration over curved landscapes.Scientific reports · 2025Article
- Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues.eLife · 2023Article
- Morphomigrational description as a new approach connecting cell's migration with its morphology.Scientific reports · 2023Article
- Interpreting T-cell search "strategies" in the light of evolution under constraints.PLoS computational biology · 2023Article
- Correlation between speed and turning naturally arises for sparsely sampled cell movements.Physical biology · 2023Article
- Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks.F1000Research · 2023Article
- T cell morphodynamics reveal periodic shape oscillations in three-dimensional migration.Journal of the Royal Society, Interface · 2022Article
- Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system.Materials today. Bio · 2022Review
- Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Local actin dynamics couple speed and persistence in a cellular Potts model of cell migration.Biophysical journal · 2021Article
- Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche.Cell stem cell · 2020Article
- Review
- Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo.eLife · 2020Article
- Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory.Scientific reports · 2019Article
- Optimal estimation of drift and diffusion coefficients in the presence of static localization error.Physical review. E · 2019Article
- Identifying the mechanism for superdiffusivity in mouse fibroblast motility.PLoS computational biology · 2019Article
- Distributed Adaptive Search in T Cells: Lessons From Ants.Frontiers in immunology · 2019Review
- Spatial Lymphocyte Dynamics in Lymph Nodes Predicts the Cytotoxic T Cell Frequency Needed for HIV Infection Control.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The three-dimensional positions of immune cells can be tracked in live tissues precisely as a function of time using two-photon microscopy. However, standard methods of analysis used in the field and experimental artifacts can bias interpretations and obscure important aspects of cell migration such as directional migration and non-Brownian walk statistics. Therefore, methods were developed for minimizing drift artifacts, identifying directional and anisotropic (asymmetric) migration, and classifying cell migration statistics. These methods were applied to describe the migration statistics of CD8+ T cells in uninflamed lymph nodes. Contrary to current models, CD8+ T cell statistics are not well described by a straightforward persistent random walk model. Instead, a model in which one population of cells moves via Brownian-like motion and another population follows variable persistent random walks with noise reproduces multiple statistical measures of CD8+ T cell migration in the lymph node in the absence of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.