ArticleNature communications2015
A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Behavioral and Exumbrellar Integumental Defenses in Jellyfish: The Hydromedusan Spirocodon saltatrix Releases Oxidized Derivatives of Unsaturated Fatty Acids Potentially to Avoid Predation and Bacterial Biofouling.Journal of chemical ecology · 2026Article
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Evolutionary Process Underlying Receptor Gene Expansion and Cellular Divergence of Olfactory Sensory Neurons in Honeybees.Molecular biology and evolution · 2025Article
- Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps.BMC biology · 2025Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Antennal Transcriptome Screening and Identification of Chemosensory Proteins in the Double-Spine European Spruce Bark Beetle,International journal of molecular sciences · 2024Article
- Genome-wide identification and characterization of the chemosensory relative protein genes in Rhus gall aphid Schlechtendalia chinensis.BMC genomics · 2023Article
- Structural screens identify candidate human homologs of insect chemoreceptors and crypticeLife · 2023Article
- Review
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor.eLife · 2020Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
- Article
- Genome of the Parasitoid Wasp Diachasma alloeum, an Emerging Model for Ecological Speciation and Transitions to Asexual Reproduction.Genome biology and evolution · 2019Article
- Identification of putative fecundity-related gustatory receptor genes in the brown planthopper Nilaparvata lugens.BMC genomics · 2018Article
- Genome Sequence of the Wheat Stem Sawfly, Cephus cinctus, Representing an Early-Branching Lineage of the Hymenoptera, Illuminates Evolution of Hymenopteran Chemoreceptors.Genome biology and evolution · 2018Article
- Whole-head recording of chemosensory activity in the marine annelidOpen biology · 2018Article
- Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of GRs (Gustatory receptor-like (Grl) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two Grls in the cnidarian Nematostella vectensis, NvecGrl1 and NvecGrl2, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms. NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of NvecGrl1 causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome Grl from the sea urchin Strongylocentrotus purpuratus displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.