ArticleBiophysical journal2015
Quantitative analysis and modeling probe polarity establishment in C. elegans embryos.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Nematic structures contribute to robust zygotic polarization in C. elegans.PLoS computational biology · 2026Article
- Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues.Science advances · 2026Article
- Classification of first embryonic division stages of multiple Caenorhabditis species by deep learning.NPJ systems biology and applications · 2025Article
- Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry.eLife · 2025Article
- Design principles for selective polarization of PAR proteins by cortical flows.The Journal of cell biology · 2023Article
- Describing the movement of molecules in reduced-dimension models.Communications biology · 2021Article
- Article
- Guiding self-organized pattern formation in cell polarity establishment.Nature physics · 2019Article
- Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes.Nature communications · 2018Article
- The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.Development (Cambridge, England) · 2017Review
- Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.Nature cell biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell polarity underlies many aspects of metazoan development and homeostasis, and relies notably on a set of PAR proteins located at the cell cortex. How these proteins interact in space and time remains incompletely understood. We performed a quantitative assessment of polarity establishment in one-cell stage Caenorhabditis elegans embryos by combining time-lapse microscopy and image analysis. We used our extensive data set to challenge and further specify an extant mathematical model. Using likelihood-based calibration, we uncovered that cooperativity is required for both anterior and posterior PAR complexes. Moreover, we analyzed the dependence of polarity establishment on changes in size or temperature. The observed robustness of PAR domain dimensions in embryos of different sizes is in agreement with a model incorporating fixed protein concentrations and variations in embryo surface/volume ratio. In addition, we quantified the dynamics of polarity establishment over most of the viable temperatures range of C. elegans. Modeling of these data suggests that diffusion of PAR proteins is the process most affected by temperature changes, although cortical flows appear unaffected. Overall, our quantitative analytical framework provides insights into the dynamics of polarity establishment in a developing system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.