Evidence map›Paper›PMID 25692575›Full record

ArticleAIDS patient care and STDs2015

A qualitative study of patient motivation to adhere to combination antiretroviral therapy in South Africa.

Francois van Loggerenberg, Debra Gray, Santhanalakshmi Gengiah, Pinky Kunene, Tanuja N Gengiah, Kogieleum Naidoo, Alison D Grant, CAPRISA 058 Study Team

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francois van Loggerenberg1 The Global Health Network, Centre for Tropical Medicine and Global Health, University of Oxford , Oxford, United Kingdom .
Debra Gray
Santhanalakshmi Gengiah
Pinky Kunene
Tanuja N Gengiah
Kogieleum Naidoo
Alison D Grant
CAPRISA 058 Study Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Taken as prescribed, that is, with high adherence, combination antiretroviral therapy (ART) has changed HIV infection and disease from being a sure predictor of death to a manageable chronic illness. Adherence, however, is difficult to achieve and maintain. The CAPRISA 058 study was conducted between 2007 and 2009 to test the efficacy of individualized motivational counselling to enhance ART adherence in South Africa. As part of the overall trial, a qualitative sub-study was conducted, including 30 individual interviews and four focus group discussions with patients in the first 9 months of ART initiation. Data were inductively analyzed, using thematic analysis, to identify themes central to ART adherence in this context. Four themes emerged that characterize the participants' experiences and high motivation to adhere to ART. Participants in this study were highly motivated to adhere, as they acknowledged that ART was 'life-giving', in the face of a large amount of morbidity and mortality. They were further supported by techniques of routine remembering, and highlighted the importance of good social support and access to supportive healthcare workers, to their continued success in negotiating their treatment. Participants in the current study told us that their adherence motivation is enhanced by free accessible care, approachable and supportive healthcare workers, broad social acceptance of ART, and past first-hand experiences with AIDS-related co-morbidity and mortality. Programs that include specific attention to these aspects of care will likely be successful in the long term.

Indexed as

MotivationAdultAnti-Retroviral AgentsFemaleFocus GroupsHealth PersonnelHIV InfectionsHumansInterviews as TopicMaleMedication AdherenceQualitative ResearchSocial StigmaSocial SupportSocioeconomic FactorsAnti-Retroviral Agents

Identifiers

PMID25692575
PMCPMC4410570

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.