ArticleNature communications2015
Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 105 citations in OpenAlex.
- Host genetics and diet jointly shape the microbiome of Drosophila melanogaster but do not predict lifespan or age-related traits.Biogerontology · 2026Article
- Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease.Frontiers in microbiology · 2026Review
- Microbiome composition shapes temperature tolerance in a Hawaiian picture-winged Drosophila.The Journal of experimental biology · 2025Article
- Structure, function, and quantitative biology of the Drosophila gut microbiome.Current opinion in microbiology · 2025Review
- Lack of significant effect of gut microbiota on weight gain in newly emerged worker honeybee.Royal Society open science · 2025Article
- Intestinal stem cell niche: An upcoming area of immense importance in gastrointestinal disorders.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Infection with the entomopathogenic nematodes Steinernema alters the Drosophila melanogaster larval microbiome.PloS one · 2025Article
- Comparative analysis of the microbiota of sand fly vectors of Leishmania major and L. tropica in a mixed focus of cutaneous leishmaniasis in southeast Tunisia; ecotype shapes the bacterial community structure.PLoS neglected tropical diseases · 2024Article
- The effect of microbiome on social spacing inmicroPublication biology · 2024Article
- Effects of host species on microbiota composition in Phlebotomus and Lutzomyia sand flies.Parasites & vectors · 2023Article
- Recent trends in insect gut immunity.Frontiers in immunology · 2023Review
- Gut microbiota-stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis.iMeta · 2022Review
- Bacterial Metabolism and Transport Genes Are Associated with the Preference of Drosophila melanogaster for Dietary Yeast.Applied and environmental microbiology · 2022Article
- Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitness.PLoS genetics · 2022Article
- Microbiota Influences Fitness and Timing of Reproduction in the Fruit Fly Drosophila melanogaster.Microbiology spectrum · 2021Article
- Horizontal gene transfer-mediated bacterial strain variation affects host fitness in Drosophila.BMC biology · 2021Article
- The Impact of Microbiome and Microbiota-Derived Sodium Butyrate onMetabolites · 2021Article
- Article
- The impact of the gut microbiome on memory and sleep inThe Journal of experimental biology · 2021Article
- Patterns of Microbiome Variation Among Infrapopulations of Permanent Bloodsucking Parasites.Frontiers in microbiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Animals bear communities of gut microorganisms with substantial effects on animal nutrition, but the host genetic basis of these effects is unknown. Here we use Drosophila to demonstrate substantial among-genotype variation in the effects of eliminating the gut microbiota on five host nutritional indices (weight, protein, lipid, glucose and glycogen contents); this includes variation in both the magnitude and direction of microbiota-dependent effects. Genome-wide association studies to identify the genetic basis of the microbiota-dependent variation reveal polymorphisms in largely non-overlapping sets of genes associated with variation in the nutritional traits, including strong representation of conserved genes functioning in signalling. Key genes identified by the GWA study are validated by loss-of-function mutations that altered microbiota-dependent nutritional effects. We conclude that the microbiota interacts with the animal at multiple points in the signalling and regulatory networks that determine animal nutrition. These interactions with the microbiota are probably conserved across animals, including humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.