ArticleRNA biology2014
Regulation of gene expression through inefficient splicing of U12-type introns.
Article in RNA biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Identity rather than 3D position informs splicing of rare introns in the human genome.iScience · 2026Article
- The SARS-CoV-2 UTR's Intrudes Host RBP's and Modulates Cellular Splicing.Advances in virology · 2023Article
- Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing.Molecular cell · 2022Article
- Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Alternative Splicing in Human Biology and Disease.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Chromosomal instability by mutations in the novel minor spliceosome component CENATAC.The EMBO journal · 2021Article
- Genome-wide analysis of CCHC-type zinc finger (ZCCHC) proteins in yeast, Arabidopsis, and humans.Cellular and molecular life sciences : CMLS · 2020Review
- Comprehensive database and evolutionary dynamics of U12-type introns.Nucleic acids research · 2020Article
- Review
- Differential isoform expression and alternative splicing in sex determination in mice.BMC genomics · 2019Article
- RNA Binding Motif Protein 48 Is Required for U12 Splicing and Maize Endosperm Differentiation.The Plant cell · 2019Article
- Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defectiveRNA (New York, N.Y.) · 2018Article
- RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing.Molecular cell · 2018Article
- IntEREst: intron-exon retention estimator.BMC bioinformatics · 2018Article
- The emerging role of minor intron splicing in neurological disorders.Cell stress · 2018Review
- A Role of U12 Intron in Proper Pre-mRNA Splicing of PlantFrontiers in plant science · 2018Article
- Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.PLoS genetics · 2017Article
- Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.International journal of molecular sciences · 2016Article
- Non-coding RNAs and disease: the classical ncRNAs make a comeback.Biochemical Society transactions · 2016Review
- Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.Genes & development · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
U12-type introns are a rare class of nuclear introns that are removed by a dedicated U12-dependent spliceosome and are thought to regulate the expression of their target genes owing through their slower splicing reaction. Recent genome-wide studies on the splicing of U12-type introns are now providing new insights on the biological significance of this parallel splicing machinery. The new studies cover multiple different organisms and experimental systems, including human patient cells with mutations in the components of the minor spliceosome, zebrafish with similar mutations and various experimentally manipulated human cells and Arabidopsis plants. Here, we will discuss the potential implications of these studies on the understanding of the mechanism and regulation of the minor spliceosome, as well as their medical implications.
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