Evidence map›Paper›PMID 25692110›Full record

ArticleJournal of stroke2015

Impacts of rapid recanalization and collateral circulation on clinical outcome after intraarterial thrombolysis.

Hye Seon Jeong, Hyon-Jo Kwon, Hee-Jung Song, Hyeon-Song Koh, Yong Soo Kim, Ju Hun Lee, Jee Eun Shin, Suk Hoon Lee, Jei Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Outcomes between in-hospital stroke and community-onset stroke after thrombectomy: Propensity-score matching analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hye Seon JeongRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurology, Hospital and School of Medicine, Daejeon, Korea.
Hyon-Jo KwonRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurosurgery, Hospital and School of Medicine, Daejeon, Korea.
Hee-Jung SongRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurology, Hospital and School of Medicine, Daejeon, Korea.
Hyeon-Song KohRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurosurgery, Hospital and School of Medicine, Daejeon, Korea.
Yong Soo KimRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurology, Hospital and School of Medicine, Daejeon, Korea.
Ju Hun LeeRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurology, Hospital and School of Medicine, Daejeon, Korea.
Jee Eun ShinDepartment of Information and Statistics, College of Natural Science, Chungnam National University, Daejeon, Korea.
Suk Hoon LeeDepartment of Information and Statistics, College of Natural Science, Chungnam National University, Daejeon, Korea.
Jei KimRegional Cerebrovascular Center, Hospital and School of Medicine, chungnam National University, Daejeon, Korea. ; Department of Neurology, Hospital and School of Medicine, Daejeon, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeRapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT.

methodsWe retrospectively evaluated the clinical and radiological data of 134 consecutive patients who underwent IAT for intracranial artery occlusion. The interval from symptom onset to recanalization after IAT (onset-to-recanalization time) as an estimate of the probability of good clinical outcome (modified Rankin scale 0-2) was calculated in patients with collateral circulation in the ischemic hemisphere, which was rated poor (0/1 American Society of Interventional and Therapeutic Neuroradiology criteria) or good (2-4). Changes in National Institute of Health Stroke Scale (NHISS) score before and after IAT and modified Rankins scale scores 3 months after discharge were compared with respect to onset-to-recanalization time.

resultsIn patients with good collateral circulation, the estimated onset-to-recanalization time for a 0.5 probability of a good clinical outcome was 347 minutes; with poor collateral circulation, it was 172 minutes for a 0.2 probability of good clinical outcome. Outcome analyses according to onset-to-recanalization time showed patients recanalized <6 hours had lower NHISS scores (<4.5, 4.5-6, >6 hours of onset-to-recanalization time, and non-recanalization: 5.1, 6.9, 11.9, and 19.8, respectively) at discharge and higher percentages of good clinical outcome (69%, 66.7%, 21.9%, and 0%, respectively) 3 months after IAT.

conclusionsThe time window to expect a high probability of a good clinical outcome after IAT is highly dependent on the collateral circulation.

Indexed as

Clinical outcomeCollateral circulationIschemic strokeRecanalizationThrombolysis

Identifiers

PMID25692110
PMCPMC4325642

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.