ArticleFrontiers in aging neuroscience2015
Widespread increase of functional connectivity in Parkinson's disease with tremor: a resting-state FMRI study.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Deep-learning-optimized microstate network analysis for early Parkinson's disease with mild cognitive impairment.Cognitive neurodynamics · 2024Article
- Subregions of the fusiform gyrus are differentially involved in the attentional mechanism supporting visual mental imagery in depression.Brain imaging and behavior · 2024Article
- Resting-state functional connectivity of the occipital cortex in different subtypes of Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease.Brain sciences · 2023Article
- Regional white matter hyperintensity volume in Parkinson's disease and associations with the motor signs.Annals of clinical and translational neurology · 2023Article
- Predicting poststroke dyskinesia with resting-state functional connectivity in the motor network.Neurophotonics · 2023Article
- Automatic depression diagnosis through hybrid EEG and near-infrared spectroscopy features using support vector machine.Frontiers in neuroscience · 2023Article
- Topological analysis of functional connectivity in Parkinson's disease.Frontiers in neuroscience · 2023Article
- Disrupted topological organization of white matter structural networks in high myopia patients revealed by diffusion kurtosis imaging and tractography.Frontiers in neuroscience · 2023Article
- Magnetic resonance imaging image analysis of the therapeutic effect and neuroprotective effect of deep brain stimulation in Parkinson's disease based on a deep learning algorithm.International journal for numerical methods in biomedical engineering · 2022Article
- Disrupted topological organization of resting-state functional brain networks in cerebral small vessel disease.Human brain mapping · 2022Article
- Disrupted morphological grey matter networks in early-stage Parkinson's disease.Brain structure & function · 2021Article
- A Correlation Analysis between SNPs and ROIs of Alzheimer's Disease Based on Deep Learning.BioMed research international · 2021Article
- Dynamic Network Connectivity Reveals Markers of Response to Deep Brain Stimulation in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
- Altered Brain Functional Network in Subtypes of Parkinson's Disease: A Dynamic Perspective.Frontiers in aging neuroscience · 2021Article
- Altered Brain Network Centrality in Patients with Adult Strabismus with Amblyopia: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Acupuncture Modulates Disrupted Whole-Brain Network after Ischemic Stroke: Evidence Based on Graph Theory Analysis.Neural plasticity · 2020Article
- Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.Human brain mapping · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a clinically heterogeneous disease in the symptomatology dominated by tremor, akinesia, or rigidity. Focusing on PD patients with tremor, this study investigated their discoordination patterns of spontaneous brain activity by combining voxel-wise centrality, seed-based functional connectivity, and network efficiency methods. Sixteen patients and 20 matched healthy controls (HCs) were recruited and underwent structural and resting-state functional MRI scan. Compared with the HCs, the patients exhibited increased centrality in the frontal, parietal, and occipital regions while decreased centrality in the cerebellum anterior lobe and thalamus. Seeded at these regions, a distributed network was further identified that encompassed cortical (default mode network, sensorimotor cortex, prefrontal and occipital areas) and subcortical (thalamus and basal ganglia) regions and the cerebellum and brainstem. Graph-based analyses of this network revealed increased information transformation efficiency in the patients. Moreover, the identified network correlated with clinical manifestations in the patients and could distinguish the patients from HCs. Morphometric analyses revealed decreased gray matter volume in multiple regions that largely accounted for the observed functional abnormalities. Together, these findings provide a comprehensive view of network disorganization in PD with tremor and have important implications for understanding neural substrates underlying this specific type of PD.
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