Evidence map›Paper›PMID 25691819›Full record

ReviewContemporary oncology (Poznan, Poland)2015

Epigenetic mechanisms of induced pluripotency.

Marta Gładych, Anastazja Andrzejewska, Urszula Oleksiewicz, Marcos R H Estécio

Open access · goldAbstract readReview
In one paragraph

Review in Contemporary oncology (Poznan, Poland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. How Does Reprogramming to Pluripotency Affect Genomic Imprinting?Frontiers in cell and developmental biology · 2019
    Review
  11. Review
  12. Review
  13. Article
  14. Application of induced pluripotency in cancer studies.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Marta GładychDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
Anastazja AndrzejewskaDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
Urszula OleksiewiczDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
Marcos R H EstécioDepartment of Molecular Carcinogenesis, Division of Basic Science Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Poznan University of Medical Sciences · PLGreater Poland Cancer Center · PLThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.

Indexed as

chromatin modificationsDNA methylationepigeneticsinduced pluripotent stem cells

Identifiers

PMID25691819
PMCPMC4322530
OpenAlexW2160761342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.