ArticleMediators of inflammation2015
Modulation of extracellular ATP content of mast cells and DRG neurons by irradiation: studies on underlying mechanism of low-level-laser therapy.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study.Scientific reports · 2019Trial
- CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats.Purinergic signalling · 2025Article
- Influence of acupuncture intensity on analgesic effects in AA rat models.Frontiers in bioengineering and biotechnology · 2024Article
- Hybrid Therapeutic Device (CUHK-OA-M2) for Relieving Symptoms Induced by Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2023Article
- Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats.Purinergic signalling · 2021Article
- Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia.Purinergic signalling · 2020Article
- Quantum biology in low level light therapy: death of a dogma.Annals of translational medicine · 2020Article
- Purines Change at Acupoints along the Pericardium Meridian in Healthy and Myocardial Ischemic Rats.Chinese journal of integrative medicine · 2019Article
- Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats.Journal of pain research · 2018Article
- A Retrospective Study of Non-thermal Laser Therapy for the Treatment of Toenail Onychomycosis.The Journal of clinical and aesthetic dermatology · 2017Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-level-laser therapy (LLLT) is an effective complementary treatment, especially for anti-inflammation and wound healing in which dermis or mucus mast cells (MCs) are involved. In periphery, MCs crosstalk with neurons via purinergic signals and participate in various physiological and pathophysiological processes. Whether extracellular ATP, an important purine in purinergic signaling, of MCs and neurons could be modulated by irradiation remains unknown. In this study, effects of red-laser irradiation on extracellular ATP content of MCs and dorsal root ganglia (DRG) neurons were investigated and underlying mechanisms were explored in vitro. Our results show that irradiation led to elevation of extracellular ATP level in the human mast cell line HMC-1 in a dose-dependent manner, which was accompanied by elevation of intracellular ATP content, an indicator for ATP synthesis, together with [Ca(2+)]i elevation, a trigger signal for exocytotic ATP release. In contrast to MCs, irradiation attenuated the extracellular ATP content of neurons, which could be abolished by ARL 67156, a nonspecific ecto-ATPases inhibitor. Our results suggest that irradiation potentiates extracellular ATP of MCs by promoting ATP synthesis and release and attenuates extracellular ATP of neurons by upregulating ecto-ATPase activity. The opposite responses of these two cell types indicate complex mechanisms underlying LLLT.
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