Evidence map›Paper›PMID 25691802›Full record

ArticleJournal of materials science2015

Laminar Tendon Composites with Enhanced Mechanical Properties.

Kyle A Alberti, Jeong-Yun Sun, Widusha R Illeperuma, Zhigang Suo, Qiaobing Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Autograft Long Head Biceps Tendon Can Be Used as a Scaffold for Biologically Augmenting Rotator Cuff Repairs.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2022
    Article
  3. A Rapid and Convenient Approach to Construct Porous Collagen MembranesFrontiers in bioengineering and biotechnology · 2021
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyle A AlbertiDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, 02155, USA.
Jeong-Yun SunSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, 02138, USA ; Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge MA, 02138, USA ; Department of Materials Science and Engineering, Seoul National University, Seoul, 151-744 Korea.
Widusha R IlleperumaSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, 02138, USA ; Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge MA, 02138, USA.
Zhigang SuoSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, 02138, USA ; Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge MA, 02138, USA.
Qiaobing XuDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts, 02155, USA.

Funding

Fabrication and characterization of constructs from decellularized tendonR03EB017402 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI XU, QIAOBING · 2013 to 2014
$147k
NIBIB NIH HHS R03 EB017402
6 · The paper itself

Abstract

purposeA strong isotropic material that is both biocompatible and biodegradable is desired for many biomedical applications, including rotator cuff repair, tendon and ligament repair, vascular grafting, among others. Recently, we developed a technique, called "bioskiving" to create novel 2D and 3D constructs from decellularized tendon, using a combination of mechanical sectioning, and layered stacking and rolling. The unidirectionally aligned collagen nanofibers (derived from sections of decellularized tendon) offer good mechanical properties to the constructs compared with those fabricated from reconstituted collagen.

methodsIn this paper, we studied the effect that several variables have on the mechanical properties of structures fabricated from tendon slices, including crosslinking density and the orientation in which the fibers are stacked.

resultsWe observed that following stacking and crosslinking, the strength of the constructs is significantly improved, with crosslinked sections having an ultimate tens ile strength over 20 times greater than non-crosslinked samples, and a modulus nearly 50 times higher. The mechanism of the mechanical failure mode of the tendon constructs with or without crosslinking was also investigated.

conclusionsThe strength and fiber organization, combined with the ability to introduce transversely isotropic mechanical properties makes the laminar tendon composites a biocompatiable material that may find future use in a number of biomedical and tissue engineering applications.

Indexed as

biomaterialscollagenmechanical propertiestendon

Identifiers

PMID25691802
PMCPMC4327911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.