ArticleProceedings of the National Academy of Sciences of the United States of America2015
Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed.
- Evolutionary Consequences of Repeated Loss of Distyly in Linum.Genome biology and evolution · 2026Article
- Local Genetic Signatures of a Global Weed: Population Structure and Ecological Drivers ofEcology and evolution · 2026Article
- Somatic genome-doubling is the most parsimonious route to allopolyploidy.The New phytologist · 2026Review
- Introgression across ploidies contributes to genetic diversity in introduced urbanbioRxiv : the preprint server for biology · 2026Article
- Heat alters fruit morphology and severely limits reproduction but not growth in a widespread urban weed.bioRxiv : the preprint server for biology · 2026Article
- Optimization of functional genetics tools for a model tetraploid Capsella bursa-pastoris, with focus on homoeolog-aware gene editing.Transgenic research · 2026Article
- Genome analyses and breeding of polyploid crops.Nature plants · 2025Review
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Conservation Implications for the Iberian Narrow EndemicEcology and evolution · 2025Article
- Diploidization in a wild rice allopolyploid is both episodic and gradual.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance.The plant genome · 2025Review
- Oryza genome evolution through a tetraploid lens.Nature genetics · 2025Article
- The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation.Nature genetics · 2025Article
- Chromosome-Scale Assembly of Capsella orientalis, Maternal Progenitor of Cosmopolitan Allotetraploid C. bursa-pastoris.Genome biology and evolution · 2025Article
- Review
- Accurate Inference of the Polyploid Continuum Using Forward-Time Simulations.Molecular biology and evolution · 2024Article
- Dosage-sensitive maternal siRNAs determine hybridization success in Capsella.Nature plants · 2024Article
- Ploidy as a leaky reproductive barrier: mechanisms, rates and evolutionary significance of interploidy gene flow.Annals of botany · 2024Review
- Biased Retention of Environment-Responsive Genes Following Genome Fractionation.Molecular biology and evolution · 2024Article
- Dominance between self-incompatibility alleles determines the mating system ofEvolution letters · 2024Article
21 more citing papers are in PubMed but not listed here.
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16 authors.
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Abstract
Whole-genome duplication (WGD) events have occurred repeatedly during flowering plant evolution, and there is growing evidence for predictable patterns of gene retention and loss following polyploidization. Despite these important insights, the rate and processes governing the earliest stages of diploidization remain poorly understood, and the relative importance of genetic drift, positive selection, and relaxed purifying selection in the process of gene degeneration and loss is unclear. Here, we conduct whole-genome resequencing in Capsella bursa-pastoris, a recently formed tetraploid with one of the most widespread species distributions of any angiosperm. Whole-genome data provide strong support for recent hybrid origins of the tetraploid species within the past 100,000-300,000 y from two diploid progenitors in the Capsella genus. Major-effect inactivating mutations are frequent, but many were inherited from the parental species and show no evidence of being fixed by positive selection. Despite a lack of large-scale gene loss, we observe a decrease in the efficacy of natural selection genome-wide due to the combined effects of demography, selfing, and genome redundancy from WGD. Our results suggest that the earliest stages of diploidization are associated with quantitative genome-wide decreases in the strength and efficacy of selection rather than rapid gene loss, and that nonfunctionalization can receive a "head start" through a legacy of deleterious variants and differential expression originating in parental diploid populations.
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