ArticleJournal of diabetes science and technology2015
A Negative Correlation Between Blood Glucose and Acetone Measured in Healthy and Type 1 Diabetes Mellitus Patient Breath.
Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541484 (Ketone Monitoring in T1D), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
Who cites it
15 citing papers in PubMed.
- Breathomics in Diabetes Management: A Noninvasive Approach for Precision Health Monitoring.Journal of diabetes research · 2026Review
- Nanowire Array Breath Acetone Sensor for Diabetes Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Metal Oxide Gas Sensors to Study Acetone Detection Considering Their Potential in the Diagnosis of Diabetes: A Review.Molecules (Basel, Switzerland) · 2023Review
- Two-Dimensional TiBiosensors · 2022Article
- Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Commercial and Scientific Solutions for Blood Glucose Monitoring-A Review.Sensors (Basel, Switzerland) · 2022Review
- Non-Invasive Blood Glucose Monitoring Technology: A Review.Sensors (Basel, Switzerland) · 2020Review
- Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors.Diagnostics (Basel, Switzerland) · 2020Article
- Review of Non-invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone.Sensors (Basel, Switzerland) · 2020Review
- Enhanced Photo-Assisted Acetone Gas Sensor and Efficient Photocatalytic Degradation Using Fe-Doped Hexagonal and Monoclinic WONanomaterials (Basel, Switzerland) · 2020Article
- Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy.Sensors (Basel, Switzerland) · 2019Article
- Microcontroller Implementation of Support Vector Machine for Detecting Blood Glucose Levels Using Breath Volatile Organic Compounds.Sensors (Basel, Switzerland) · 2019Article
- Highly Sensitive Room-Temperature Sensor Based on Nanostructured K₂W₇OSensors (Basel, Switzerland) · 2018Article
- Sensors for Enhanced Detection of Acetone as a Potential Tool for Noninvasive Diabetes Monitoring.Sensors (Basel, Switzerland) · 2018Review
- Sensing Technologies for Detection of Acetone in Human Breath for Diabetes Diagnosis and Monitoring.Diagnostics (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExhaled acetone analysis has long been recognized as a supplementary tool for diagnosis and monitoring diabetes, especially type 1 diabetes. It is essential, therefore to determine the relationship between exhaled acetone concentration and glucose in blood. Usually, a direct linear correlation between this both compounds has been expected. However, in some cases we can observe a reverse correlation. When blood glucose was increasing, breath acetone declined.
methodsThe breath analysis as a supplementary tool for diagnosing and monitoring diabetes makes sense only in case of utilization of portable analyzers. This need has created a market for gas sensors. However, commercially available acetone gas sensors are developed for measuring samples at several tens part per million. The exhaled acetone concentration was measured using commercial acetone gas sensor (TGS 822, 823 Figaro, Arlington Heights, IL, USA Inc) with micropreconcentrator in low temperature cofired ceramics. The reference analyzer-mass spectrometry (HPR-20 QIC, Hiden Analytical, Warrington, UK) was used.
resultsTwenty-two healthy volunteers with no history of any respiratory disease participated in the research, as did 31 patients diagnosed with type 1 diabetes. Respectively, 3 healthy volunteer and 5 type 1 diabetes mellitus subjects with reverse trend were selected. The linear fitting coefficient various from 0.1139 to 0.9573. Therefore, it is necessary to determine the correlation between blood glucose concentrations and under different conditions, for example, insulin levels, as well as correlate the results with clinical tests, for example, Hb1Ac.
conclusionsIt is well known that the concentration of acetone is strongly influenced by diet, insulin treatment, and so on. Therefore, much more complex analysis with long-term measurements are required. Thus, presented results should be regarded as tentative, and validation studies with the analysis of clinical test and in a large number of patients, including control groups, need to be carried out.
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