Evidence map›Paper›PMID 25691631›Full record

ArticleAntimicrobial agents and chemotherapy2015

Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites.

Ehab Mossaad, Wakako Furuyama, Masahiro Enomoto, Satoru Kawai, Katsuhiko Mikoshiba, Shin-ichiro Kawazu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Combining IPCurrent research in microbial sciences · 2023
    Article
  2. Review
  3. Calcium in the Backstage of Malaria Parasite Biology.Frontiers in cellular and infection microbiology · 2021
    Review
  4. InsP3 Signaling in Apicomplexan Parasites.Current topics in medicinal chemistry · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Ehab MossaadNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan College of Veterinary Medicine, Sudan University of Science and Technology, Khartoum, Sudan.
Wakako FuruyamaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Masahiro EnomotoPrincess Margaret Cancer Centre, Toronto, Canada.
Satoru KawaiLaboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi, Japan.
Katsuhiko MikoshibaLaboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Japan.
Shin-ichiro KawazuNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan skawazu@obihiro.ac.jp.
Obihiro University of Agriculture and Veterinary Medicine · JPDokkyo Medical University · JPGifu University · JPPrincess Margaret Cancer Centre · CARIKEN Center for Brain Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB). The CQ resistance-reversing activity of 2-APB, which showed the same efficacy as verapamil, was also observed in an in vivo mouse infection model with the CQ-resistant Plasmodium chabaudi AS(30CQ) strain.

Indexed as

AnimalsAntimalarialsChloroquineFemaleInhibitory Concentration 50MalariaMiceMice, Inbred ICRPlasmodium falciparumVerapamilAntimalarialsChloroquineVerapamil

Identifiers

PMID25691631
PMCPMC4394803
OpenAlexW1989421050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.