ArticleAntimicrobial agents and chemotherapy2015
Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Adaptive evolution of extensive drug resistance and persistence in epidemic ST11 KPC-producingAntimicrobial agents and chemotherapy · 2025Article
- Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistantFrontiers in cellular and infection microbiology · 2025Article
- From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.Microbiology spectrum · 2023Article
- Molecular characterization of colistin resistance genes in a high-risk ST101/KPC-2 clone of Klebsiella pneumoniae in a University Hospital of Split, Croatia.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Characteristics of antibiotic resistance mechanisms and genes ofOpen medicine (Warsaw, Poland) · 2023Review
- Recent Advances in Nanotechnology for the Management ofBiosensors · 2022Review
- Causes of polymyxin treatment failure and new derivatives to fill the gap.The Journal of antibiotics · 2022Review
- Rescuing humanity by antimicrobial peptides against colistin-resistant bacteria.Applied microbiology and biotechnology · 2022Review
- Article
- Characterization of Amino Acid Substitution W20S in MgrB Involved in Polymyxin Resistance in Klebsiella pneumoniae.Microbiology spectrum · 2022Article
- Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply.Evolution, medicine, and public health · 2022Article
- Global epidemiology, genetic environment, risk factors and therapeutic prospects ofFrontiers in cellular and infection microbiology · 2022Review
- Phenotypic Changes Associated WithFrontiers in cellular and infection microbiology · 2022Article
- Genotyping of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Colistin Resistance Among Multiple Sequence Types ofFrontiers in microbiology · 2021Article
- Impact ofFrontiers in microbiology · 2021Article
- Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.Antimicrobial agents and chemotherapy · 2020Article
- Absence ofAntibiotics (Basel, Switzerland) · 2020Article
- Comparison of Fitness Cost and Virulence in Chromosome- and Plasmid-Mediated Colistin-ResistantFrontiers in microbiology · 2020Article
- Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.The Journal of infection · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.
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