ArticleJournal of bacteriology2015
An Escherichia coli mutant that makes exceptionally long cells.
Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
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- Evolutionary Advantage of Cell Size Control.Physical review letters · 2025Article
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- Functional analysis of theFrontiers in microbiology · 2024Article
- Identification of host factors limiting the overexpression of recombinant Cu, Zn superoxide dismutase in Escherichia coli.Biotechnology letters · 2020Article
- Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A Markovian Approach towards Bacterial Size Control and Homeostasis in Anomalous Growth Processes.Scientific reports · 2018Article
- Thinking big: the tunability of bacterial cell size.FEMS microbiology reviews · 2017Review
- Influences of Adhesion Variability on the "Living" Dynamics of Filamentous Bacteria in Microfluidic Channels.Molecules (Basel, Switzerland) · 2016Article
- Regulation of Growth, Cell Shape, Cell Division, and Gene Expression by Second Messengers (p)ppGpp and Cyclic Di-GMP in Mycobacterium smegmatis.Journal of bacteriology · 2016Article
- How much territory can a single E. coli cell control?Frontiers in microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAlthough Escherichia coli is a very small (1- to 2-μm) rod-shaped cell, here we describe an E. coli mutant that forms enormously long cells in rich media such as Luria broth, as long indeed as 750 μm. These extremely elongated (eel) cells are as long as the longest bacteria known and have no internal subdivisions. They are metabolically competent, elongate rapidly, synthesize DNA, and distribute cell contents along this length. They lack only the ability to divide. The concentration of the essential cell division protein FtsZ is reduced in these eel cells, and increasing this concentration restores division. IMPORTANCE: Escherichia coli is usually a very small bacterium, 1 to 2 μm long. We have isolated a mutant that forms enormously long cells, 700 times longer than the usual E. coli cell. E. coli filaments that form under other conditions usually die within a few hours, whereas our mutant is fully viable even when it reaches such lengths. This mutant provides a useful tool for the study of aspects of E. coli physiology that are difficult to investigate with small cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.