Evidence map›Paper›PMID 25691465›Full record

ArticleGenes & development2015

The Ino80 complex prevents invasion of euchromatin into silent chromatin.

Yong Xue, Christopher Van, Suman K Pradhan, Trent Su, Jason Gehrke, Benjamin G Kuryan, Tasuku Kitada, Ajay Vashisht, Nancy Tran, James Wohlschlegel and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 46 citations in OpenAlex.

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  14. Chromatin regulation and dynamics in stem cells.Current topics in developmental biology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yong XueDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Christopher VanProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Suman K PradhanDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Trent SuDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Jason GehrkeDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Benjamin G KuryanDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Tasuku KitadaDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Ajay VashishtDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Nancy TranDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
James WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Craig L PetersonProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Siavash K KurdistaniDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA;
Michael F CareyDepartment of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA; mcarey@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Massachusetts Chan Medical School · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Interplay Between Chromatin and Co-Activator ComplexesR01GM074701 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F · 2005 to 2025
$6.7M
YEAST CHROMATIN STRUCTURE/FUNCTIONR01GM054096 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PETERSON, CRAIG L · 1997 to 2017
$5.7M
Analysis of the yeast SWI1, SWI2, and SWI3 proteinsR37GM049650 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PETERSON, CRAIG L · 2006 to 2015
$4.9M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Dynamics of Histone Acetylation in Cancer Cell PhysiologyR01CA178415 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURDISTANI, SIAVASH · 2013 to 2017
$1.6M
Elongation of Yeast Pol II Through NucleosomesR01GM085002 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F · 2008 to 2011
$1.2M
NCI NIH HHS CA178415NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA178415NIGMS NIH HHS GM085002NIGMS NIH HHS GM54096NIGMS NIH HHS R01 GM054096NIGMS NIH HHS R01 GM074701NIGMS NIH HHS R01GM074701NIGMS NIH HHS R01 GM085002NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R37 GM049650
6 · The paper itself

Abstract

Here we show that the Ino80 chromatin remodeling complex (Ino80C) directly prevents euchromatin from invading transcriptionally silent chromatin within intergenic regions and at the border of euchromatin and heterochromatin. Deletion of Ino80C subunits leads to increased H3K79 methylation and noncoding RNA polymerase II (Pol II) transcription centered at the Ino80C-binding sites. The effect of Ino80C is direct, as it blocks H3K79 methylation by Dot1 in vitro. Heterochromatin stimulates the binding of Ino80C in vitro and in vivo. Our data reveal that Ino80C serves as a general silencing complex that restricts transcription to gene units in euchromatin.

Indexed as

Binding SitesChromatinEuchromatinGene Expression Regulation, FungalGene SilencingHistone-Lysine N-MethyltransferaseMethylationNuclear ProteinsProtein BindingRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsChromatinDot1 protein, S cerevisiaeEuchromatinHistone-Lysine N-MethyltransferaseINO80 complex, S cerevisiaeNuclear ProteinsRNA Polymerase IISaccharomyces cerevisiae ProteinsDot1H3K79 methylationheterochromatinIno80silencingSir proteins

Identifiers

PMID25691465
PMCPMC4335291
OpenAlexW2149989570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.