ArticleAmerican journal of hematology2015
Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease.
Article in American journal of hematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.American journal of human genetics · 2016Pooled it
- Next-generation diabetes diagnostics: spectrochemical staging of red blood cells using vibrational spectroscopy.Journal of advanced research · 2026Article
- Inverse Association between the Omega-3 Index and Neutrophil-Lymphocyte Ratio: Pooled Results from Four Supplementation Trials.The Journal of nutrition · 2026Article
- Differences Between Glycemia Estimates from Hemoglobin A1c and Continuous Glucose Monitoring and Their Association with Complete Blood Counts.Diabetes technology & therapeutics · 2026Article
- A single postoperative red cell distribution width measurement predicts short- and long-term mortality in surgical patients.Wiener medizinische Wochenschrift (1946) · 2026Article
- Can baseline red blood cell distribution width predict outcomes in peripheral T-cell lymphoma patients?Annals of hematology · 2026Article
- The Predictive Value of Hemoglobin-to-Red Blood Cell Distribution Width Ratio for the Prognosis of Patients with Aortic Dissection: Based on the Medical Information Mart for Intensive Care-IV Database.Anatolian journal of cardiology · 2025Article
- Red Cell Distribution Width (RDW), Platelets and Platelet Index MPV/PLT Ratio as Specific Time Point Predictive Variables of Survival Outcomes in COVID-19 Hospitalized Patients.Journal of clinical medicine · 2025Article
- Transformer-based artificial intelligence on single-cell clinical data for homeostatic mechanism inference and rational biomarker discovery.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.Nature communications · 2025Article
- Integrating the AEuropean journal of medical research · 2025Article
- Article
- Association of preoperative red blood cell width and postoperative 30-day mortality in patients undergoing non-cardiac surgery: a retrospective cohort study using propensity-score matching.Perioperative medicine (London, England) · 2024Article
- Review
- A unified metric of human immune health.Nature medicine · 2024Article
- Association between elevated preoperative red cell distribution width and mortality after brain tumor craniotomy.Neurosurgical review · 2024Article
- Article
- Changes in RDW according to prognostic predictors in newly diagnosed multiple myeloma.Scientific reports · 2024Article
- Red Blood Cell Distribution Width Predicts Mortality in Hospitalized Patients with Severe Fever with Thrombocytopenia Syndrome.Journal of inflammation research · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Increased red blood cell (RBC) volume variation (RDW) has recently been shown to predict a wide range of mortality and morbidity: death due to cardiovascular disease, cancer, infection, renal disease, and more; complications in heart failure and coronary artery disease, advanced stage and worse prognosis in many cancers, poor outcomes in autoimmune disease, and many more. The mechanisms by which all of these diseases lead to increased RDW are unknown. Here we use a semi-mechanistic mathematical model of in vivo RBC population dynamics to dissect the factors controlling RDW and show that elevated RDW results largely from a slight reduction in the in vivo rate of RBC turnover. RBCs become smaller as they age, and a slight reduction in the rate of RBC turnover allows smaller cells to continue circulating, expanding the low-volume tail of the RBC population's volume distribution, and thereby increasing RDW. Our results show that mildly extended RBC lifespan is a previously unrecognized homeostatic adaptation common to a very wide range of pathologic states, likely compensating for subtle reductions in erythropoietic output. A mathematical model-based estimate of the clearance rate may provide a novel early-warning biomarker for a wide range of morbidity and mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.