ReviewViruses2015
The role of RNA interference (RNAi) in arbovirus-vector interactions.
Review in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 159 citations in OpenAlex.
- SFTSV NSs protein is a tick antiviral RNAi response suppressor.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Blood feeding, microbiota, and layered mosquito immunity: from pathway phenotypes to vector competence.Frontiers in immunology · 2026Review
- Disrupting vector competence: exploring radiofrequency exposure as a novel approach to mosquito-borne disease prevention in a changing climate.Pathogens and global health · 2025Review
- Repeated thermal stress exposure inmSphere · 2025Article
- Differential effect of acuteOne health (Amsterdam, Netherlands) · 2025Article
- Sex-Biased Gene Expression of RNAi Pathway Components in the Sea Lice Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2025Article
- The PAZ domain ofRNA (New York, N.Y.) · 2025Article
- Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches.Virology journal · 2025Review
- Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions.Current research in parasitology & vector-borne diseases · 2025Review
- Pan-flavivirus analysis reveals sfRNA-independent, 3' UTR-biased siRNA production from an insect-specific flavivirus.Journal of virology · 2024Article
- 2'-O-methyltransferase-deficient yellow fever virus: Restricted replication in the midgut and secondary tissues of Aedes aegypti mosquitoes severely limits dissemination.PLoS pathogens · 2024Article
- Review
- Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses.PLoS neglected tropical diseases · 2024Article
- Complex transmission epidemiology of neglected Australian arboviruses: diverse non-human vertebrate hosts and competent arthropod invertebrate vectors.Frontiers in microbiology · 2024Review
- Recognition of Arboviruses by the Mosquito Immune System.Biomolecules · 2023Review
- RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquitoProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterisation of the antiviral RNA interference response to Toscana virus in sand fly cells.PLoS pathogens · 2023Article
- Metagenomic analysis reveals the virome profiles ofFrontiers in cellular and infection microbiology · 2023Article
- Vector-virus interaction affects viral loads and co-occurrence.BMC biology · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which arbovirus replication and transmission could be controlled in arthropod vectors. During the intervening period, research on RNAi has defined many of the components and mechanisms of this antiviral pathway in arthropods, yet a number of unexplored questions remain. RNAi refers to RNA-mediated regulation of gene expression. Originally, the term described silencing of endogenous genes by introduction of exogenous double-stranded (ds)RNA with the same sequence as the gene to be silenced. Further research has shown that RNAi comprises three gene regulation pathways that are mediated by small RNAs: the small interfering (si)RNA, micro (mi)RNA, and Piwi-interacting (pi)RNA pathways. The exogenous (exo-)siRNA pathway is now recognized as a major antiviral innate immune response of arthropods. More recent studies suggest that the piRNA and miRNA pathways might also have important roles in arbovirus-vector interactions. This review will focus on current knowledge of the role of the exo-siRNA pathway as an arthropod vector antiviral response and on emerging research into vector piRNA and miRNA pathway modulation of arbovirus-vector interactions. Although it is assumed that arboviruses must evade the vector's antiviral RNAi response in order to maintain their natural transmission cycles, the strategies by which this is accomplished are not well defined. RNAi is also an important tool for arthropod gene knock-down in functional genomics studies and in development of arbovirus-resistant mosquito populations. Possible arbovirus strategies for evasion of RNAi and applications of RNAi in functional genomics analysis and arbovirus transmission control will also be reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.