ArticleGenome medicine2014
DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.
Article in Genome medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns.Oncotarget · 2015Trial
- Integrated Bioinformatics Analysis of Differentially Expressed RNA-Binding Proteins in Human Gliomas.Cellular and molecular neurobiology · 2025Article
- RMBase v3.0: decode the landscape, mechanisms and functions of RNA modifications.Nucleic acids research · 2024Article
- Novel ratio-metric features enable the identification of new driver genes across cancer types.Scientific reports · 2022Article
- LOTUS: A single- and multitask machine learning algorithm for the prediction of cancer driver genes.PLoS computational biology · 2019Article
- CGenomics, proteomics & bioinformatics · 2019Article
- Article
- QuaDMutEx: quadratic driver mutation explorer.BMC bioinformatics · 2017Article
- Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.Oncogene · 2017Article
- Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.Endocrine-related cancer · 2017Article
- PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias.Leukemia · 2017Article
- Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin.The Journal of clinical endocrinology and metabolism · 2016Article
- Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes.Briefings in bioinformatics · 2016Review
- LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.BMC bioinformatics · 2016Article
- The Role of MIEF2 in Cisplatin Sensitivity in KIRP Patients: Insights from Four-gene Mitochondrial Fusion RNA Markers.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor samples. We have identified driver genes in the genomic data of 34 tumor types derived from existing exploratory projects such as The Cancer Genome Atlas and from studies investigating the usefulness of genomic information in the clinical settings. DOTS-Finder is available at https://cgsb.genomics.iit.it/wiki/projects/DOTS-Finder/.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.