ArticleJournal of materials science. Materials in medicine2015
Infusion of iodine-based contrast agents into poly(p-dioxanone) as a radiopaque resorbable IVC filter.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- 3D-Printed Radiopaque Bioresorbable Stents to Improve Device Visualization.Advanced healthcare materials · 2022Article
- Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs.ACS biomaterials science & engineering · 2022Article
- The application of inferior vena cava filters in orthopaedics and current research advances.Frontiers in bioengineering and biotechnology · 2022Review
- Multifunctional Biodegradable Vascular PLLA Scaffold with Improved X-ray Opacity, Anti-Inflammation, and Re-Endothelization.Polymers · 2021Article
- Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions.Medical physics · 2021Article
- Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites.Materialia · 2020Article
- In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model.Biomaterials science · 2020Article
- Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures.Acta pharmaceutica Sinica. B · 2018Review
- In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Safety and Efficacy of an Absorbable Filter in the Inferior Vena Cava to Prevent Pulmonary Embolism in Swine.Radiology · 2017Article
- Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles.Scientific reports · 2017Article
- A Critical Review of Available Retrievable Inferior Vena Cava Filters and Future Directions.Seminars in interventional radiology · 2016Review
- Accurate micro-computed tomography imaging of pore spaces in collagen-based scaffold.Journal of materials science. Materials in medicine · 2016Article
- Inferior Vena Cava Filters: Indications, Outcomes, and Evidence.Current treatment options in cardiovascular medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
To determine the feasibility of infusing resorbable inferior vena cava (IVC) filter with iodine-based contrast agents to produce a radiopaque, computed tomography (CT)-visible IVC filter. Infused poly(p-dioxanone) (PPDO) was obtained by incubating PPDO in different concentrations of 4-iodobenzoyl chloride (IBC) and 2,3,5-triiodobenzoic acid (TIBA). Characterizations of infused and nascent PPDO were done using elemental analysis, micro-CT, tensile strength analysis, scanning electron microscopy, and differential scanning calorimetry. Elemental analysis showed percentage loading of 1.07 ± 0.08 for IBC and 0.73 ± 0.01 for TIBA. The iodine loading remained the same within 2 weeks for TIBA but decreased to about 80 % with IBC when subjected to physiological conditions. Micro-CT images showed increased attenuation of the infused PPDO compared with the nascent PPDO. The Hounsfield unit values for infused and nascent sutures were 110 ± 40 and 153 ± 53 for PPDO infused with 2 mg/mL IBC and TIBA, respectively, but only 11.35 ± 2 for nascent PPDO. In contrast the HU for bone was 116 ± 37. Tensile strength analysis showed maximum loads of 1.01 ± 0.43 kg and 10.02 ± 0.54 kg for IBC and TIBA, respectively, and 10.10 ± 0.64 kg for nascent PPDO. Scanning electron microscopy showed that the morphology of the PPDO surface did not change after coating and preliminary cytotoxicity assay showed no killing effect on Hela cells. PPDO infused with a contrast agent is significantly more radiopaque than nascent PPDO on micro-CT imaging. This radiopacity could allow the position and integrity of infused resorbable IVC filter to be monitored while it is in place, thus increasing its safety and efficacy as a medical device.
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