Evidence map›Paper›PMID 25690556›Full record

ArticlePsycho-oncology2015

Posttraumatic stress and depressive symptoms in renal cell carcinoma: association with quality of life and utility of single-item distress screening.

Seema Malhotra Thekdi, Kathrin Milbury, Amy Spelman, Qi Wei, Christopher Wood, Surena F Matin, Nizar Tannir, Eric Jonasch, Louis Pisters, Lorenzo Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psycho-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Evaluation of coping as a mediator of the relationship between stressful life events and cancer-related distress.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017
    Trial
  5. Trial
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  9. Anxiety, depression, urinary continence, and sexuality in patients undergoing radical prostatectomy: preliminary findings.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  10. Review
  11. Emotional state and cancer-related self-efficacy as affecting resilience and quality of life in kidney cancer patients: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
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  13. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seema Malhotra ThekdiDepartment of Psychiatry, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kathrin MilburyDepartment of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Amy SpelmanDepartment of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Qi WeiDepartment of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Christopher WoodDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Surena F MatinDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nizar TannirDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Eric JonaschDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Louis PistersDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lorenzo CohenDepartment of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Biobehavioral Effects of Emotional Expression in CancerR01CA090966 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2002 to 2006
$2.5M
Couple-Based Mind-Body Program for Lung Cancer Patients and their PartnersK01AT007559 · NCCIH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILBURY, KATHRIN · 2013 to 2017
$652k
NCCIH NIH HHS K01 AT007559NCI NIH HHS R01CA09096NCI NIH HHS R01 CA090966
6 · The paper itself

Abstract

objectiveThe purpose of this study was to examine the prevalence of posttraumatic stress symptoms (PTSS) in patients with renal cell carcinoma (RCC), the associations and co-occurrence between PTSS, depressive, and other cancer-related symptoms and the ability of a single-item distress question to identify patients with PTSS.

methodsPatients with stage I-IV RCC completed assessments of depressive symptoms (Center for Epidemiologic Studies Depression Scale), PTSS (Impact of Event Scale), cancer-related symptoms (MD Anderson Symptom Inventory), fatigue (Brief Fatigue Inventory), and sleep disturbance (Pittsburgh Sleep Quality Index). We used the distress item on the MD Anderson Symptom Inventory as a distress screener and general linear model analyses to test study hypotheses.

resultsOf the 287 patients (29% stage IV; 42% female; mean age = 58 years), 46% (n = 131) reported psychiatric symptoms with 15% (n = 44) reporting comorbid clinical levels of depressive symptoms and PTSS, 24% (n = 70) PTSS alone, and 6% (n = 17) depressive symptoms alone. Controlling for age, gender, and stage, patients with comorbid depressive symptoms and PTSS reported more cancer-related symptoms (p < 0.0001), fatigue (p < 0.0001), and sleep disturbance (p = 0.0003) than those with PTSS alone and more cancer-related symptoms (p = 0.002) and fatigue (p = 0.09) than those with depressive symptoms alone. Sensitivity analyses revealed that 26.9% of negative cases on the distress item fell within the clinical range of the Impact of Event Scale and 9.3% of negative cases met caseness on the Center for Epidemiologic Studies Depression Scale.

conclusionsPosttraumatic stress symptoms occurred both independently and comorbid with depressive symptoms in patients with RCC. PTSS were correlated with overall cancer symptom burden. Single-item distress screening was less sensitive in detecting PTSS than depressive symptoms. Therefore, additional screening strategies are required in the clinical setting.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Renal CellComorbidityDepressionFemaleHumansMaleMass ScreeningMiddle AgedPrevalenceQuality of LifeSensitivity and SpecificityStress Disorders, Post-Traumatic

Identifiers

PMID25690556
PMCPMC4539280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.