ArticleSensors (Basel, Switzerland)2015
Amplification of the signal intensity of fluorescence-based fiber-optic biosensors using a Fabry-Perot resonator structure.
Article in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A High-Birefringence Microfiber Sagnac-Interferometer Biosensor Based on the Vernier Effect.Sensors (Basel, Switzerland) · 2018Article
- Using a Hexagonal Mirror for Varying Light Intensity in the Measurement of Small-Angle Variation.Sensors (Basel, Switzerland) · 2016Article
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6 authors.
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Abstract
Fluorescent biosensors have been widely used in biomedical applications. To amplify the intensity of fluorescence signals, this study developed a novel structure for an evanescent wave fiber-optic biosensor by using a Fabry-Perot resonator structure. An excitation light was coupled into the optical fiber through a laser-drilled hole on the proximal end of the resonator. After entering the resonator, the excitation light was reflected back and forth inside the resonator, thereby amplifying the intensity of the light in the fiber. Subsequently, the light was used to excite the fluorescent molecules in the reactive region of the sensor. The experimental results showed that the biosensor signal was amplified eight-fold when the resonator reflector was formed using a 92% reflective coating. Furthermore, in a simulation, the biosensor signal could be amplified 20-fold by using a 99% reflector.
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