ArticleEuropean journal of nuclear medicine and molecular imaging2015
Cortical activity during olfactory stimulation in multiple chemical sensitivity: a (18)F-FDG PET/CT study.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03732092 (The Effects of Olfactory Stimulation on Diagnosis and Prognosis of Patients With Disorders of Consciousness), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Olfactory Stimulation on Diagnosis and Prognosis of Patients With Disorders of Consciousness
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021Pooled it
- Perspectives on multisensory perception disruption in idiopathic environmental intolerance: a systematic review.International archives of occupational and environmental health · 2018Pooled it
- Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives.Journal of occupational and environmental medicine · 2018Pooled it
- Multiple Chemical Sensitivity and the SLC Gene Superfamily: A Case-Control Study.International journal of molecular sciences · 2025Article
- Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities.NPJ Parkinson's disease · 2025Review
- Multiple Chemical Sensitivity: an Italian prevalence multicentric survey.Frontiers in public health · 2025Article
- [Application research and development of objective examination of olfactory function].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Metabolic correlates of olfactory dysfunction in COVID-19 and Parkinson's disease (PD) do not overlap.European journal of nuclear medicine and molecular imaging · 2022Article
- Altered glucose metabolism of the olfactory-related cortices in anosmia patients with traumatic brain injury.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Utility of SPECT Functional Neuroimaging of Pain.Frontiers in psychiatry · 2021Article
- Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.International journal of environmental research and public health · 2020Article
- Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.International journal of molecular sciences · 2019Article
- Chemical intolerance: involvement of brain function and networks after exposure to extrinsic stimuli perceived as hazardous.Environmental health and preventive medicine · 2019Review
- PET and SPECT in psychiatry: the past and the future.European journal of nuclear medicine and molecular imaging · 2019Article
- Evaluation of Task-Related Brain Activity: Is There a Role forBioMed research international · 2019Review
- Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study.Environmental health : a global access science source · 2018Article
- Metabolic and Electrophysiological Changes Associated to Clinical Improvement in Two Severely Traumatized Subjects Treated With EMDR-A Pilot Study.Frontiers in psychology · 2018Article
- Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.PloS one · 2018Article
- Cerebral metabolic changes related to clinical parameters in idiopathic anosmic patients during olfactory stimulation: a pilot investigation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.BMJ open · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.
methodsTwo (18)F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in (18)F-FDG uptake were analysed by statistical parametric mapping (SPM2).
resultsIn controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.
conclusionThe results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.