Evidence map›Paper›PMID 25690530›Full record

ArticleJournal of the International AIDS Society2015

Active and latent tuberculosis among HIV-positive injecting drug users in Indonesia.

Hinta Meijerink, Rudi Wisaksana, Mery Lestari, Intan Meilana, Lydia Chaidir, Andre J A M van der Ven, Bachti Alisjahbana, Reinout van Crevel

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hinta MeijerinkDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Rudi WisaksanaHealth Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia.
Mery LestariDepartment of Internal Medicine, Faculty of Medicine, Hasan Sadikin Hospital, Padjadjaran University, Bandung, Indonesia.
Intan MeilanaDepartment of Internal Medicine, Faculty of Medicine, Hasan Sadikin Hospital, Padjadjaran University, Bandung, Indonesia.
Lydia ChaidirHealth Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia.
Andre J A M van der VenDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Bachti AlisjahbanaHealth Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia.
Reinout van CrevelDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands; Reinout.vanCrevel@radboudumc.nl.
Padjadjaran University · IDRadboud University Medical Center · NLDr. Hasan Sadikin General Hospital · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInjecting drug use (IDU) is associated with tuberculosis but few data are available from low-income settings. We examined IDU in relation to active and latent tuberculosis (LTBI) among HIV-positive individuals in Indonesia, which has a high burden of tuberculosis and a rapidly growing HIV epidemic strongly driven by IDU.

methodsActive tuberculosis was measured prospectively among 1900 consecutive antiretroviral treatment (ART)-naïve adult patients entering care in a clinic in West Java. Prevalence of LTBI was determined cross-sectionally in a subset of 518 ART-experienced patients using an interferon-gamma release assay.

resultsPatients with a history of IDU (53.1%) more often reported a history of tuberculosis treatment (34.8% vs. 21.9%, p < 0.001), more often received tuberculosis treatment during follow-up (adjusted HR = 1.71; 95% CI: 1.25-2.35) and more often had bacteriologically confirmed tuberculosis (OR = 1.67; 95% CI: 0.94-2.96). LTBI was equally prevalent among people with and without a history of IDU (29.1 vs. 30.4%, NS). The risk estimates did not change after adjustment for CD4 cell count or ART.

conclusionsHIV-positive individuals with a history of IDU in Indonesia have more active tuberculosis, with similar rates of LTBI. Within the HIV clinic, LTBI screening and isoniazid preventive therapy may be prioritized to patients with a history of IDU.

Indexed as

AdultFemaleHIV InfectionsHumansIndonesiaLatent TuberculosisMaleSubstance Abuse, IntravenousTuberculosiscohort studieshuman immunodeficiency virusintravenouslatent tuberculosis infectionMycobacterium tuberculosissubstance abuse

Identifiers

PMID25690530
PMCPMC4331401
OpenAlexW2036807569

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.