ReviewNutrients2015
Low-normal thyroid function and novel cardiometabolic biomarkers.
Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2025Article
- Gender Differences in Prevalence and Clinical Correlates of Initial-Treatment and Drug-Naïve Bipolar Disorder Patients With Metabolic Syndrome: A Cross-Sectional Study.Alpha psychiatry · 2025Article
- Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex.The Journal of clinical endocrinology and metabolism · 2025Article
- Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study.Lipids in health and disease · 2025Observational
- Magnitude, Pattern, and Associated Factors of Thyroid Dysfunction in Diabetic Patients at Debre Markos Referral Hospital in North-West Ethiopia: A Cross-Sectional Hospital-based Study.Ethiopian journal of health sciences · 2025Article
- Association between oxidative balance score and thyroid function and all-cause mortality in euthyroid adults.Scientific reports · 2025Article
- Thyroid Hormone Resistance Indices and Their Correlations With Insulin Resistance in Chinese Euthyroid Subjects.International journal of endocrinology · 2025Article
- Multi-omics analysis of the potential association between metabolic features of hypothyroidism in the first half of pregnancy and Th17/Treg balance.Frontiers in immunology · 2025Article
- Lipoprotein Ratios: Correlation With Glycated Hemoglobin (HbA1c) Among Thyroid Disorders' Patients.Cureus · 2024Article
- Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The association between the thyroid feedback quantile-based index and serum uric acid in U.S. adults.European journal of medical research · 2023Article
- Higher Sensitivity to Thyroid Hormones May Be Linked to Maintaining the Healthy Metabolic Condition in People with Obesity: New Insight from NHANES.Obesity facts · 2023Article
- Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism.The Journal of clinical endocrinology and metabolism · 2022Article
- Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function.BMC endocrine disorders · 2022Article
- Higher Free Triiodothyronine Is Associated With Higher HDL Particle Concentration and Smaller HDL Particle Size.The Journal of clinical endocrinology and metabolism · 2022Article
- Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects.Journal of clinical medicine · 2021Article
- Association of Subclinical Hypothyroidism and Cardiovascular Disease With Mortality.JAMA network open · 2020Article
- Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Obesity.Frontiers in endocrinology · 2020Article
- Association between Thyroid-Stimulating Hormone Levels and Non-Alcoholic Fatty Liver Disease Is Not Independent from Metabolic Syndrome Criteria.European thyroid journal · 2018Article
- High-normal serum thyrotropin levels and increased glycemic variability in type 2 diabetic patients.Endocrine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept is emerging that low-normal thyroid function, i.e., either higher thyroid-stimulating hormone or lower free thyroxine levels within the euthyroid reference range, could contribute to the development of atherosclerotic cardiovascular disease. It is possible that adverse effects of low-normal thyroid function on cardiovascular outcome may be particularly relevant for specific populations, such as younger people and subjects with high cardiovascular risk. Low-normal thyroid function probably relates to modest increases in plasma total cholesterol, low density lipoprotein cholesterol, triglycerides and insulin resistance, but effects on high density lipoprotein (HDL) cholesterol and non-alcoholic fatty liver disease are inconsistent. Low-normal thyroid function may enhance plasma cholesteryl ester transfer, and contribute to an impaired ability of HDL to inhibit oxidative modification of LDL, reflecting pro-atherogenic alterations in lipoprotein metabolism and HDL function, respectively. Low-normal thyroid function also confers lower levels of bilirubin, a strong natural anti-oxidant. Remarkably, all these effects of low-normal thyroid functional status appear to be more outspoken in the context of chronic hyperglycemia and/or insulin resistance. Collectively, these data support the concept that low-normal thyroid function may adversely affect several processes which conceivably contribute to the pathogenesis of atherosclerotic cardiovascular disease, beyond effects on conventional lipoprotein measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.