Evidence map›Paper›PMID 25690418›Full record

Trial reportNutrients2015

Pilot dietary intervention with heat-stabilized rice bran modulates stool microbiota and metabolites in healthy adults.

Amy M Sheflin, Erica C Borresen, Melissa J Wdowik, Sangeeta Rao, Regina J Brown, Adam L Heuberger, Corey D Broeckling, Tiffany L Weir, Elizabeth P Ryan

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amy M SheflinDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. amymarie@mac.com.
Erica C BorresenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. Erica.Borresen@colostate.edu.
Melissa J WdowikDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. melissa.wdowik@colostate.edu.
Sangeeta RaoDepartment of Clinical Sciences, Animal Population Health Institute, Colorado State University, Fort Collins, CO 80523, USA. Sangeeta.Rao@colostate.edu.
Regina J BrownCancer Center of the Rockies, University of Colorado Health, Fort Collins, CO 80522, USA. Regina.Brown@uchealth.org.
Adam L HeubergerDepartment of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523, USA. Adam.Heuberger@colostate.edu.
Corey D BroecklingProteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO 80523, USA. Corey.Broeckling@colostate.edu.
Tiffany L WeirDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA. Tiffany.Weir@colostate.edu.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. E.P.Ryan@colostate.edu.
Colorado State University · USUniversity of Colorado Health · US

Funding

Dietary Rice Bran Phytochemicals and Microbial Metabolites for Colon ChemopreventR21CA161472 · NCI · COLORADO STATE UNIVERSITY · PI RYAN, ELIZABETH P, WEIR, TIFFANY L · 2012 to 2013
$339k
NCI NIH HHS R21 CA161472NCI NIH HHS R21CA161472
6 · The paper itself

Abstract

Heat-stabilized rice bran (SRB) has been shown to regulate blood lipids and glucose, modulate gut mucosal immunity and inhibit colorectal cancer in animal and human studies. However, SRB's effects on gut microbial composition and metabolism and the resulting implications for health remain largely unknown. A pilot, randomized-controlled trial was developed to investigate the effects of eating 30 g/day SRB on the stool microbiome and metabolome. Seven healthy participants consumed a study meal and snack daily for 28 days. The microbiome and metabolome were characterized using 454 pyrosequencing and gas chromatography-mass spectrometry (GC-MS) at baseline, two and four weeks post-intervention. Increases in eight operational taxonomic units (OTUs), including three from Bifidobacterium and Ruminococcus genera, were observed after two and four weeks of SRB consumption (p<0.01). Branched chain fatty acids, secondary bile acids and eleven other putative microbial metabolites were significantly elevated in the SRB group after four weeks. The largest metabolite change was a rice bran component, indole-2-carboxylic acid, which showed a mean 12% increase with SRB consumption. These data support the feasibility of dietary SRB intervention in adults and support that SRB consumption can affect gut microbial metabolism. These findings warrant future investigations of larger cohorts evaluating SRB's effects on intestinal health.

Indexed as

MetabolomeOryzaAdultBifidobacteriumBile Acids and SaltsCarboxylic AcidsDiet TherapyFatty AcidsFecesFemaleGas Chromatography-Mass SpectrometryHumansIndolesMalePilot ProjectsRuminococcusBile Acids and SaltsCarboxylic AcidsFatty Acidsindole-2-carboxylic acidIndoles

Identifiers

PMID25690418
PMCPMC4344588
OpenAlexW2050584826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.