ArticleInternational journal of environmental research and public health2015
Production of the allergenic protein Alt a 1 by Alternaria isolates from working environments.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Assessment of Resistance Induction in Mungbean against Alternaria alternata through RNA Interference.The plant pathology journal · 2024Article
- Identification and genetic diversity ofInternational journal of molecular epidemiology and genetics · 2022Article
- Temporal variability in the allergenicity of airborne Alternaria spores.Medical mycology · 2019Article
- Innate Immunity Induced by the Major Allergen Alt a 1 From the FungusFrontiers in immunology · 2018Article
- Alternaria alternata (Fr.) Keissl with mutation G143A in the Cyt b gene is the source of a difficult-to-control allergen.Environmental science and pollution research international · 2018Article
- The Incidence ofThe plant pathology journal · 2017Article
- Validation of reference genes for normalization of gene expression by qRT-PCR in a resveratrol-producing entophytic fungus (Alternaria sp. MG1).AMB Express · 2016Article
- Characterisation of a flavonoid ligand of the fungal protein Alt a 1.Scientific reports · 2016Article
- Successful Management of Fungal Keratitis byCase reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to evaluate the ability of Alternaria isolates from workplaces to produce Alt a 1 allergenic protein, and to analyze whether technical materials (cellulose, compost, leather) present within the working environment stimulate or inhibit Alt a 1 production (ELISA test). Studies included identification of the isolated molds by nucleotide sequences analyzing of the ITS1/ITS2 regions, actin, calmodulin and Alt a 1 genes. It has been shown that Alternaria molds are significant part of microbiocenosis in the archive, museum, library, composting plant and tannery (14%-16% frequency in the air). The presence of the gene encoding the Alt a 1 protein has been detected for the strains: Alternaria alternata, A. lini, A. limoniasperae A. nobilis and A. tenuissima. Environmental strains produced Alt a 1 at higher concentrations (1.103-6.528 ng/mL) than a ATCC strain (0.551-0.975 ng/mL). It has been shown that the homogenization of the mycelium and the use of ultrafiltration allow a considerable increase of Alt a 1 concentration. Variations in the production of Alt a 1 protein, depend on the strain and extraction methods. These studies revealed no impact of the technical material from the workplaces on the production of Alt a 1 protein.
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Registered trials
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