ArticleInternational journal of environmental research and public health2015
Antimicrobial resistance in commensal Escherichia coli from pigs during metaphylactic trimethoprim and sulfamethoxazole treatment and in the post-exposure period.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
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- Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens.Microbiology spectrum · 2026Article
- Antimicrobial Use and Epidemiological Resistance Profiles of CommensalAntibiotics (Basel, Switzerland) · 2026Article
- The impact of early-life rearing conditions on the porcine gut microbiota and immune system.Animal microbiome · 2025Article
- Genomic Insights of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Metagenomic comparison of the faecal and environmental resistome on Irish commercial pig farms with and without zinc oxide and antimicrobial usage.Animal microbiome · 2023Article
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- Susceptibility ofAntibiotics (Basel, Switzerland) · 2023Article
- Real-World Data on Antibiotic Group Treatment in European Livestock: Drivers, Conditions, and Alternatives.Antibiotics (Basel, Switzerland) · 2022Article
- Prevalence and characterisation of antimicrobial resistance genes and class 1 and 2 integrons in multiresistant Escherichia coli isolated from poultry production.Scientific reports · 2022Article
- Identification and Antibiotic Profiling ofFrontiers in microbiology · 2021Article
- Antibacterial Activity of Bacteriocinogenic CommensalAntibiotics (Basel, Switzerland) · 2020Article
- Complexity of Antibiotic Resistance in Commensal Escherichia coli Derived from Pigs from an Intensive-Production Farm.Microbes and environments · 2018Article
- Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance.Porcine health management · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of trimethoprim (TMP) and sulfamethoxazole (SMX) resistance in commensal E. coli from pigs was tested in this study. E. coli was derived from three groups of piglets in successive stages of metaphylactic therapy and from two groups of sows 10 and 18 weeks after the treatment. MIC values of TMP and SMX were determined for a total of 352 strains. The presence of resistance genes (dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3) and class 1 and 2 integron-associated dfrA gene cassettes was tested. Resistance to TMP was very high during the administration of the antimicrobial (from 97 to 100%) and amounted to 86% and 69% in the post-exposure period; MIC > 32 mg/L. The isolates from all groups of pigs were resistant to sulfamethoxazole, with MIC > 1028 mg/L. The dfrA1 and sul1 genes (as part of integrons) dominated in E. coli from piglets, but the dfrA12 and sul1 genes were prevalent in E. coli from sows. Coexistence of the different dfrA genes was detected in 71 isolates from all groups of swine. Transcription analysis revealed that most of these genes were not transcribed, particularly gene cassettes of class 1 integrons. The research revealed a high level of resistance associated with the metaphylactic treatment, persistence and circulation of resistance in bacterial populations. Diverse genetic background with multiple and not transcribed resistance genes was observed.
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