ArticleEpilepsia2015
Burden, causes, and outcomes of people with epilepsy admitted to a rural hospital in Kenya.
Article in Epilepsia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- A systematic review of studies that estimated the burden of chronic non-communicable rare diseases using disability-adjusted life years.Orphanet journal of rare diseases · 2024Pooled it
- Prevalence, incidence, and trends of epilepsy among children and adolescents in Africa: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Article
- Status of epilepsy in the tropics: An overlooked perspective.Epilepsia open · 2023Review
- Psychometric Properties of the Persian Version of Adult Eating Behavior Questionnaire in Patients with Epilepsy.Iranian journal of medical sciences · 2022Article
- Article
- Contextualizing and pilot testing the Mental Health Gap Action Programme Intervention Guide (mhGAP-IG) to primary healthcare workers in Kilifi, Kenya.Global mental health (Cambridge, England) · 2020Article
- Epilepsy diagnosis and management of children in Kenya: review of current literature.Research and reports in tropical medicine · 2019Article
- Article
- Cognition, mood and quality-of-life outcomes among low literacy adults living with epilepsy in rural Kenya: A preliminary study.Epilepsy & behavior : E&B · 2018Article
- Prevalence, risk factors and behavioural and emotional comorbidity of acute seizures in young Kenyan children: a population-based study.BMC medicine · 2018Article
- Prevalence, risk factors, and neurobehavioral comorbidities of epilepsy in Kenyan children.Epilepsia open · 2017Article
- Magnitude and factors associated with nonadherence to antiepileptic drug treatment in Africa: A cross-sectional multisite study.Epilepsia open · 2017Article
- An overview of mental health care system in Kilifi, Kenya: results from an initial assessment using the World Health Organization's Assessment Instrument for Mental Health Systems.International journal of mental health systems · 2017Article
- Risk of convulsive epilepsy following acute seizures in Kenyan children.Epilepsia open · 2016Article
- Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
objectivePeople with epilepsy (PWE) develop complications and comorbidities often requiring admission to hospital, which adds to the burden on the health system, particularly in low-income countries. We determined the incidence, disability-adjusted life years (DALYs), risk factors, and causes of admissions in PWE. We also examined the predictors of prolonged hospital stay and death using data from linked clinical and demographic surveillance system.
methodsWe studied children and adults admitted to a Kenyan rural hospital, between January 2003 and December 2011, with a diagnosis of epilepsy. Poisson regression was used to compute incidence and rate ratios, logistic regression to determine associated factors, and the DALY package of the R-statistical software to calculate years lived with disability (YLD) and years of life lost (YLL).
resultsThe overall incidence of admissions was 45.6/100,000 person-years of observation (PYO) (95% confidence interval [95% CI] 43.0-48.7) and decreased with age (p < 0.001). The overall DALYs were 3.1/1,000 (95% CI, 1.8-4.7) PYO and comprised 55% of YLD. Factors associated with hospitalization were use of antiepileptic drugs (AEDs) (odds ratio [OR] 5.36, 95% CI 2.64-10.90), previous admission (OR 11.65, 95% CI 2.65-51.17), acute encephalopathy (OR 2.12, 95% CI 1.07-4.22), and adverse perinatal events (OR 2.87, 95% CI 1.06-7.74). Important causes of admission were epilepsy-related complications: convulsive status epilepticus (CSE) (38%), and postictal coma (12%). Age was independently associated with prolonged hospital stay (OR 1.02, 95% CI 1.00-1.04) and mortality (OR, 1.07, 95% CI 1.04-1.10). SIGNIFICANCE: Epilepsy is associated with significant number of admissions to hospital, considerable duration of admission, and mortality. Improved supply of AEDs in the community, early initiation of treatment, and adherence would reduce hospitalization of PWE and thus the burden of epilepsy on the health system.
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