Evidence map›Paper›PMID 25689043›Full record

ArticleACS chemical biology2015

A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association.

Wei Zhang, Saumya Sankaran, Or Gozani, Jikui Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wei Zhang†Department of Biochemistry, University of California, Riverside, California 92521, United States.
Saumya Sankaran‡Department of Biology, Stanford University, Stanford, California 94305, United States.
Or Gozani‡Department of Biology, Stanford University, Stanford, California 94305, United States.
Jikui Song†Department of Biochemistry, University of California, Riverside, California 92521, United States.
Stanford University · USUniversity of California, Riverside · US

Funding

Function of PHD Domain Proteins in Chromatin RegulationR01GM079641 · NIGMS · STANFORD UNIVERSITY · PI GOZANI, OR P. · 2007 to 2020
$4.5M
NIGMS NIH HHS R01 GM079641
6 · The paper itself

Abstract

Recent studies have identified several genetic mutations within the BAH domain of human Origin Recognition Complex subunit 1 (hORC1BAH), including the R105Q mutation, implicated in Meier-Gorlin Syndrome (MGS). However, the pathological role of the hORC1 R105Q mutation remains unclear. In this study, we have investigated the interactions of the hORC1BAH domain with histone H4K20me2, DNA, and the nucleosome core particle labeled with H4Kc20me2, a chemical analog of H4K20me2. Our study revealed a nucleosomal DNA binding site for hORC1BAH. The R105Q mutation reduces the hORC1BAH-DNA binding affinity, leading to impaired hORC1BAH-nucleosome interaction, which likely influences DNA replication initiation and MGS pathogenesis. This study provides an etiologic link between the hORC1 R105Q mutation and MGS.

Indexed as

MutationCongenital MicrotiaDNAElectrophoretic Mobility Shift AssayGrowth DisordersHumansMicrognathismNucleosomesOrigin Recognition ComplexPatellaDNANucleosomesORC1 protein, humanOrigin Recognition Complex

Identifiers

PMID25689043
PMCPMC4654454
OpenAlexW2331489648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.