Evidence map›Paper›PMID 25689033›Full record

ArticleMolecular nutrition & food research2015

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization.

Dongjie Wang, Lap Ho, Jeremiah Faith, Kenjiro Ono, Elsa M Janle, Pamela J Lachcik, Bruce R Cooper, Amber H Jannasch, Bruce R D'Arcy, Barbara A Williams and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 117 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 5 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 5 syntheses or guidelines pooled it, 230 citations in OpenAlex.

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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Dongjie WangCenter of Nutrition and Food Sciences, ARC center of Excellence in Plant Cell Walls, The University of Queensland, Brisbane, Queensland, Australia.
Lap HoDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Jeremiah FaithDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Kenjiro OnoDepartment of Neurology and Neurobiology and Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Elsa M JanleDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Pamela J LachcikDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Bruce R CooperBindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
Amber H JannaschBindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
Bruce R D'ArcySchool of Agriculture and Food Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Barbara A WilliamsCenter of Nutrition and Food Sciences, ARC center of Excellence in Plant Cell Walls, The University of Queensland, Brisbane, Queensland, Australia.
Mario G FerruzziDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Samara LevineDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Wei ZhaoDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Lauren DubnerDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Giulio M PasinettiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NJ, USA.
Icahn School of Medicine at Mount Sinai · USPurdue University West Lafayette · USUniversity of Queensland · AUKanazawa University · JP

Funding

Resveratrol & Natur Polyphenols: Mech of Proteolitic Clear of AB/Marambaud, PhilP01AT004511 · NCCIH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PASINETTI, GIULIO MARIA · 2007 to 2012
$8.0M
NCCIH NIH HHS P01 AT004511NCCIH NIH HHS P01AT004511-01
6 · The paper itself

Abstract

scopeGrape seed polyphenol extract (GSPE) is receiving increasing attention for its potential preventative and therapeutic roles in Alzheimer's disease (AD) and other age-related neurodegenerative disorders. The intestinal microbiota is known to actively convert many dietary polyphenols, including GSPE, to phenolic acids. There is limited information on the bioavailability and bioactivity of GSPE-derived phenolic acid in the brain. METHODS AND

resultsWe orally administered GSPE to rats and investigated the bioavailability of 12 phenolic acids known to be generated by microbiota metabolism of anthocyanidins. GSPE treatment significantly increased the content of two of the phenolic acids in the brain: 3-hydroxybenzoic acid and 3-(3´-hydroxyphenyl)propionic acid, resulting in the brain accumulations of the two phenolic acids at micromolar concentrations. We also provided evidence that 3-hydroxybenzoic acid and 3-(3´-hydroxyphenyl)propionic acid potently interfere with the assembly of β-amyloid peptides into neurotoxic β-amyloid aggregates that play key roles in AD pathogenesis.

conclusionOur observation suggests important contribution of the intestinal microbiota to the protective activities of GSPE (as well as other polyphenol preparations) in AD. Outcomes from our studies support future preclinical and clinical investigations exploring the potential contributions of the intestinal microbiota in protecting against the onset/progression of AD and other neurodegenerative conditions.

Indexed as

Gastrointestinal MicrobiomeAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAnthocyaninsBiological AvailabilityBrainFermentationGrape Seed ExtractHydroxybenzoatesIntestinesMalePeptide FragmentsPhenolsPolyphenolsPropionates3-hydroxybenzoic acid3-hydroxyphenylpropionic acidAmyloid beta-Peptidesamyloid beta-protein (1-42)AnthocyaninsGrape Seed ExtractHydroxybenzoatesPeptide Fragmentsphenolic acidPhenolsPolyphenolsPropionatesBioavailabilityGrape seed polyphenol extractPhenolic metabolitesProanthocyanidinsβ-Amyloid

Identifiers

PMID25689033
PMCPMC4498582
OpenAlexW1976544976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.