ArticleThe ISME journal2015
Positive selection is the main driving force for evolution of citrus canker-causing Xanthomonas.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Whole-Genome Analysis of a Historical Strain ofInternational journal of molecular sciences · 2026Article
- Evolution and spread ofMicrobial genomics · 2025Article
- Comparative genomic analysis uncovered phylogenetic diversity, evolution of virulence factors, and horizontal gene transfer events in tomato bacterial spotFrontiers in microbiology · 2024Article
- Insights into Superinfection Immunity Regulation of Xanthomonas axonopodis Filamentous Bacteriophage cf.Current microbiology · 2023Article
- Phylogenomic analysis of 343 Xanthomonas citri pv. citri strains unravels introduction history and dispersal paths.PLoS pathogens · 2023Article
- Assessment of beneficial effects and identification of host adaptation-associated genes of Ligilactobacillus salivarius isolated from badgers.BMC genomics · 2023Article
- Herbarium specimen sequencing allows precise dating of Xanthomonas citri pv. citri diversification history.Nature communications · 2023Article
- Core-Genome Multilocus Sequence Typing for Epidemiological and Evolutionary Analyses of Phytopathogenic Xanthomonas citri.Applied and environmental microbiology · 2023Article
- Citrus Canker Pathogen, Its Mechanism of Infection, Eradication, and Impacts.Plants (Basel, Switzerland) · 2022Review
- Prophage-mediated genome differentiation of theMicrobial genomics · 2022Article
- Comparative Genomic Analysis Uncovered Evolution of Pathogenicity Factors, Horizontal Gene Transfer Events, and Heavy Metal Resistance Traits in Citrus Canker BacteriumFrontiers in microbiology · 2021Article
- Comparative Genomics ofMicroorganisms · 2020Article
- Insights into the Metabolism and Evolution of the GenusmSystems · 2020Article
- Citrus CsACD2 Is a Target ofPlant physiology · 2020Article
- Origin and diversification of Xanthomonas citri subsp. citri pathotypes revealed by inclusive phylogenomic, dating, and biogeographic analyses.BMC genomics · 2019Article
- Deciphering how plant pathogenic bacteria disperse and meet: Molecular epidemiology ofEvolutionary applications · 2019Article
- Recent advances in the understanding of Xanthomonas citri ssp. citri pathogenesis and citrus canker disease management.Molecular plant pathology · 2018Article
- Article
- Proteomics-based identification of differentially abundant proteins reveals adaptation mechanisms of Xanthomonas citri subsp. citri during Citrus sinensis infection.BMC microbiology · 2017Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the evolutionary history and potential of bacterial pathogens is critical to prevent the emergence of new infectious bacterial diseases. Xanthomonas axonopodis subsp. citri (Xac) (synonym X. citri subsp. citri), which causes citrus canker, is one of the hardest-fought plant bacterial pathogens in US history. Here, we sequenced 21 Xac strains (14 XacA, 3 XacA* and 4 XacA(w)) with different host ranges from North America and Asia and conducted comparative genomic and evolutionary analyses. Our analyses suggest that acquisition of beneficial genes and loss of detrimental genes most likely allowed XacA to infect a broader range of hosts as compared with XacA(w) and XacA*. Recombination was found to have occurred frequently on the relative ancient branches, but rarely on the young branches of the clonal genealogy. The ratio of recombination/mutation ρ/θ was 0.0790±0.0005, implying that the Xac population was clonal in structure. Positive selection has affected 14% (395 out of 2822) of core genes of the citrus canker-causing Xanthomonas. The genes affected are enriched in 'carbohydrate transport and metabolism' and 'DNA replication, recombination and repair' genes (P<0.05). Many genes related to virulence, especially genes involved in the type III secretion system and effectors, are affected by positive selection, further highlighting the contribution of positive selection to the evolution of citrus canker-causing Xanthomonas. Our results suggest that both metabolism and virulence genes provide advantages to endow XacA with higher virulence and a wider host range. Our analysis advances our understanding of the genomic basis of specialization by positive selection in bacterial evolution.
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