Evidence map›Paper›PMID 25688763›Full record

ReviewExercise and sport sciences reviews2015

Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States.

Ilkka Heinonen, Shunsaku Koga, Kari K Kalliokoski, Timothy I Musch, David C Poole

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Aerobic capacity andEuropean journal of applied physiology · 2023
    Trial
  4. Trial
  5. PlanHabThe Journal of physiology · 2018
    Trial
  6. Trial
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Effects of fractional inspired OPhysiological reports · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Interaction of Factors Determining Critical Power.Sports medicine (Auckland, N.Z.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ilkka Heinonen1Turku PET Centre, University of Turku, Turku, Finland; 2Division of Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; 3School of Sport Science, Exercise and Health, University Of Western Australia, Crawley, Western Australia, Australia; 4Applied Physiology Laboratory, Kobe Design University, Kobe, Japan; and 5Departments of Kinesiology, Anatomy and Physiology, Kansas State University, Manhattan, KS.
Shunsaku Koga
Kari K Kalliokoski
Timothy I Musch
David C Poole

Funding

Mechanisms of Muscle Microcirculatory Dysfunction in Heart FailureR15HL108328 · NHLBI · KANSAS STATE UNIVERSITY · PI POOLE, DAVID C · 2011 to 2015
$741k
MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERR01HL050306 · NHLBI · KANSAS STATE UNIVERSITY · PI POOLE, DAVID C · 1998 to 2001
$437k
GEOMETRICAL MICROSTRUCTURE AND FUNCTION IN DIAPHRAGMR29HL050306 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI POOLE, DAVID C · 1994 to 1997
–
NHLBI NIH HHS HL-108328NHLBI NIH HHS HL-50306NHLBI NIH HHS R01 HL050306NHLBI NIH HHS R15 HL108328
6 · The paper itself

Abstract

The systematic increase in V˙O2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (Q˙O2)-to- V˙O2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased Q˙O2/V˙O2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.

Indexed as

Oxygen ConsumptionAdaptation, PhysiologicalAgingChronic DiseaseDiabetes MellitusExerciseHeart FailureHumansMuscle, SkeletalPhysical Education and TrainingRegional Blood Flow

Identifiers

PMID25688763
PMCPMC4470710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.