ArticleeLife2015
Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.Genome research · 2026Article
- Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Multi-omics analysis reveals criticaliScience · 2025Article
- Low-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes.Nature communications · 2024Article
- Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation.PLoS biology · 2024Article
- The Dynamic Interplay Between Ribosomal DNA and Transposable Elements: A Perspective From Genomics and Cytogenetics.Molecular biology and evolution · 2024Article
- Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes.Nature communications · 2023Article
- Dynamics and Impacts of Transposable Element Proliferation in the Drosophila nasuta Species Group Radiation.Molecular biology and evolution · 2022Article
- Clustering of Sex-Biased Genes and Transposable Elements in the Genome of the Medaka Fish Oryzias latipes.Genome biology and evolution · 2021Article
- Gene Conversion amongstGenes · 2021Article
- Epigenetics drive the evolution of sex chromosomes in animals and plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Gene conversion generates evolutionary novelty that fuels genetic conflicts.Current opinion in genetics & development · 2019Review
- The Role of Gene Conversion between Transposable Elements in Rewiring Regulatory Networks.Genome biology and evolution · 2019Review
- Contingency in the convergent evolution of a regulatory network: Dosage compensation in Drosophila.PLoS biology · 2019Article
- Sex and the TEs: transposable elements in sexual development and function in animals.Mobile DNA · 2019Review
- Differential retention of transposable element-derived sequences in outcrossing Arabidopsis genomes.Mobile DNA · 2019Article
- Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays.eLife · 2018Article
- Review
- Regulatory activities of transposable elements: from conflicts to benefits.Nature reviews. Genetics · 2017Review
- Single genome retrieval of context-dependent variability in mutation rates for human germline.BMC genomics · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transposable elements (TEs) allow rewiring of regulatory networks, and the recent amplification of the ISX element dispersed 77 functional but suboptimal binding sites for the dosage compensation complex to a newly formed X chromosome in Drosophila. Here we identify two linked refining mutations within ISX that interact epistatically to increase binding affinity to the dosage compensation complex. Selection has increased the frequency of this derived haplotype in the population, which is fixed at 30% of ISX insertions and polymorphic among another 41%. Sharing of this haplotype indicates that high levels of gene conversion among ISX elements allow them to 'crowd-source' refining mutations, and a refining mutation that occurs at any single ISX element can spread in two dimensions: horizontally across insertion sites by non-allelic gene conversion, and vertically through the population by natural selection. These results describe a novel route by which fully functional regulatory elements can arise rapidly from TEs and implicate non-allelic gene conversion as having an important role in accelerating the evolutionary fine-tuning of regulatory networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.