ArticleeLife2015
Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
127 citing papers in PubMed, 247 citations in OpenAlex.
- Envisaging the role of plant Small RNAs: A comprehensive review on antiviral defense mechanisms.Molecular biology reports · 2026Review
- Regulatory role of epigenetics in rice immunity against bacterial and fungal pathogens.Crop health · 2026Review
- Unlocking wheat fertility: map-based cloning spotlights anther-specific TaAGO5c as a master modulator.The Plant journal : for cell and molecular biology · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- Methionine Synthase Positively Regulates Plant Defence to Both RNA and DNA Viruses and Is Useful for Developing Broad-Spectrum Antiviral Resistance in Crops.Plant biotechnology journal · 2026Article
- Overexpression of OsAGO18 Promotes Early Seedling Development and Root Elongation in Rice.Plants (Basel, Switzerland) · 2026Article
- A viral protein disrupts rice cell wall integrity and modulates interactions with viruses and insects.Stress biology · 2026Article
- Arboviruses manipulate rice's volatile emissions, protecting insect vectors from natural enemies in the field.Science advances · 2026Article
- Small but big player: the important role of microRNAs in rice.Frontiers in plant science · 2026Review
- Article
- Diverse RNA viral effectors converge on facilitation of AGO4 degradation to promote infection.Nucleic acids research · 2025Article
- Evolutionarily New Solanaceous DCL2 Family Members Acquire Functions in Tomato.Molecular plant pathology · 2025Article
- Two Transcriptional Factors Antagonistically Fine-Tune MIR1863a to Balance Resistance and Yield Traits in Rice.Plant biotechnology journal · 2025Article
- Antiviral RNA interference in plants: Increasing complexity and integration with other biological processes.Plant communications · 2025Review
- Natural variation of the MIR168a promoter influences its activity and miR168a abundance in rice.Rice (New York, N.Y.) · 2025Article
- Immune sensing of plant viral capsid proteins.Science China. Life sciences · 2025Article
- MicroRNA528 and Its Regulatory Roles in Monocotyledonous Plants.International journal of molecular sciences · 2025Review
- Virus Isolation and Rice Protoplast Infection.Bio-protocol · 2025Article
- A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viral pathogenesis.Nature communications · 2025Article
- Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral pathogens are a major threat to rice production worldwide. Although RNA interference (RNAi) is known to mediate antiviral immunity in plant and animal models, the mechanism of antiviral RNAi in rice and other economically important crops is poorly understood. Here, we report that rice resistance to evolutionarily diverse viruses requires Argonaute18 (AGO18). Genetic studies reveal that the antiviral function of AGO18 depends on its activity to sequester microRNA168 (miR168) to alleviate repression of rice AGO1 essential for antiviral RNAi. Expression of miR168-resistant AGO1a in ago18 background rescues or increases rice antiviral activity. Notably, stable transgenic expression of AGO18 confers broad-spectrum virus resistance in rice. Our findings uncover a novel cooperative antiviral activity of two distinct AGO proteins and suggest a new strategy for the control of viral diseases in rice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.