ArticleJournal of abnormal psychology2015
Cortisol reactivity to stress among youth: stability over time and genetic variants for stress sensitivity.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Salivary cortisol in post-traumatic stress disorder: a systematic review and meta-analysis.BMC psychiatry · 2018Pooled it
- Coping, emotion regulation, and psychopathology in childhood and adolescence: A meta-analysis and narrative review.Psychological bulletin · 2017Pooled it
- Article
- Conceptual qualitative system dynamics model for simulation of perceived workload, stress and performance from industrial work content.PloS one · 2026Article
- Adding to the burden: the tendency to resonate with others' stress is linked to higher PTSD symptom severity in individuals with war-related trauma.Translational psychiatry · 2025Article
- Endogenous glucocorticoids and human immunity: Time to revisit old dogmas.Seminars in immunology · 2025Review
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Effect of yoga in medical students to reduce the level of depression, anxiety, and stress: pilot study (Goodbye Stress with Yoga GSY).BMC complementary medicine and therapies · 2024Article
- The "vestibular neuromatrix": A proposed, expanded vestibular network from graph theory in post-concussive vestibular dysfunction.Human brain mapping · 2022Article
- Repeated Sevoflurane Exposure in Neonatal Rats Enhances the Sensitivity to Pain and Traumatic Stress Later in Juvenile Life.Journal of pain research · 2022Article
- Usability, Feasibility, and Effect of a Biocueing Intervention in Addition to a Moderated Digital Social Therapy-Platform in Young People With Emerging Mental Health Problems: A Mixed-Method Approach.Frontiers in psychiatry · 2022Article
- Allostatic Stress and Inflammatory Biomarkers in Transgender and Gender Expansive Youth: Protocol for a Pilot Cohort Study.JMIR research protocols · 2021Article
- Assessing the relationship between psychosocial stressors and psychiatric resilience among Chilean disaster survivors.The British journal of psychiatry : the journal of mental science · 2020Article
- Teeth as Potential New Tools to Measure Early-Life Adversity and Subsequent Mental Health Risk: An Interdisciplinary Review and Conceptual Model.Biological psychiatry · 2020Review
- Individual variation in the cortisol response to a simulated Olympic weightlifting competition is related to changes in future competitive performance.Biology of sport · 2019Article
- Cognitive reappraisal attenuates the association between depressive symptoms and emotional response to stress during adolescence.Cognition & emotion · 2019Article
- 5-HTTLPR moderates the association between attention away from angry faces and prospective depression among youth.Journal of psychiatric research · 2017Article
- Associations of social support and stress with postpartum maternal mental health symptoms: Main effects, moderation, and mediation.Women & health · 2017Article
- Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.Neurobiology of stress · 2017Review
- A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study.Arthritis research & therapy · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Stress sensitivity may be one process that can explain why some genetically at-risk individuals are more susceptible to some types of stress-reactive psychopathologies. Dysregulation of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis, including cortisol reactivity to challenge, represents a key aspect of stress sensitivity. However, the degree of stability over time among youth, especially differential stability as a function of particular genetic variants, has not been investigated. A general community sample of children and adolescents (mean age = 11.4; 56% girls) provided a DNA sample and completed 2 separate laboratory stress challenges, across an 18-month follow-up (N = 224 at Time 1; N = 194 at Time 2), with repeated measures of salivary cortisol. Results showed that test-retest stability for several indices of cortisol reactivity across the laboratory challenge visits were significant and of moderate magnitude for the whole sample. Moreover, gene variants of several biologically plausible systems relevant for stress sensitivity (especially 5-HTTLPR and CRHR1) demonstrated differential stability of cortisol reactivity over 18-months, such that carriers of genotypes conferring enhanced environmental susceptibility exhibited greater stability of cortisol levels over time for some LHPA axis indices. Findings suggest that LHPA axis dysregulation may exhibit some trait-like aspects underlying stress sensitivity in youth, especially for those who carry genes related to greater genetic susceptibility to environmental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.