ArticleJournal of abnormal psychology2015
A two-factor model of relapse/recurrence vulnerability in unipolar depression.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis.Clinical psychology review · 2018Pooled it
- Amygdala Reactivity, Antidepressant Discontinuation, and Relapse.JAMA psychiatry · 2024Trial
- Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization.European archives of psychiatry and clinical neuroscience · 2022Trial
- A randomized controlled trial of gaze-contingent music reward therapy for major depressive disorder.Depression and anxiety · 2021Trial
- Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B.Medicine · 2018Trial
- Article
- Measuring behavioral responses to a social stressor: Does the Social Performance Rating Scale have utility beyond social anxiety disorder?Behaviour research and therapy · 2025Article
- Stress sensitivity in women with a history of recurrent versus first-episode major depression.Psychiatry research · 2025Article
- Reinforcement learning processes as forecasters of depression remission.Journal of affective disorders · 2025Article
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Stress and Psychosocial Distress Scale with Blunted Oscillatory Dynamics Serving Abstract Reasoning.Depression and anxiety · 2024Article
- Cognitive manipulation of emotional and non-emotional information in working memory of patients with depression: a rigid processing style.Frontiers in psychology · 2023Article
- Brain areas associated with resilience to depression in high-risk young women.Brain structure & function · 2021Article
- Assessing the relationship between psychosocial stressors and psychiatric resilience among Chilean disaster survivors.The British journal of psychiatry : the journal of mental science · 2020Article
- Article
- All together now: utilizing common functional change principles to unify cognitive behavioral and mindfulness-based therapies.Current opinion in psychology · 2019Review
- Emotional Biases and Recurrence in Major Depressive Disorder. Results of 2.5 Years Follow-Up of Drug-Free Cohort Vulnerable for Recurrence.Frontiers in psychiatry · 2019Article
- Altered Structural Covariance Among the Dorsolateral Prefrontal Cortex and Amygdala in Treatment-Naïve Patients With Major Depressive Disorder.Frontiers in psychiatry · 2018Article
- Attentional bias modification in depression through gaze contingencies and regulatory control using a new eye-tracking intervention paradigm: study protocol for a placebo-controlled trial.BMC psychiatry · 2016Article
- The course of major depressive disorder from childhood to young adulthood: Recovery and recurrence in a longitudinal observational study.Journal of affective disorders · 2016Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The substantial health burden associated with major depressive disorder (MDD) is a product of both its high prevalence and the significant risk of relapse, recurrence, and chronicity. Establishing recurrence vulnerability factors (VFs) could improve the long-term management of MDD by identifying the need for further intervention in seemingly recovered patients. We present a model of sensitization in depression vulnerability, with an emphasis on the integration of behavioral and neural systems accounts. Evidence suggests that VFs fall into 2 categories: dysphoric attention and dysphoric elaboration. Dysphoric attention is driven by fixation on negative life events, and is characterized behaviorally by reduced executive control, and neurally by elevated activity in the brain's salience network. Dysphoric elaboration is driven by rumination that promotes overgeneral self- and contextual appraisals, and is characterized behaviorally by dysfunctional attitudes, and neurally by elevated connectivity within normally distinct prefrontal brain networks. Although few prospective VF studies exist from which to catalogue a definitive neurobehavioral account, extant data support the value of the proposed 2-factor model. Measuring the continued presence of these 2 VFs during recovery may more accurately identify remitted patients who would benefit from targeted prophylactic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.