ArticlePlant biotechnology journal2015
Sustained NIK-mediated antiviral signalling confers broad-spectrum tolerance to begomoviruses in cultivated plants.
Article in Plant biotechnology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- The immune NIK1/RPL10/LIMYB signaling module regulates photosynthesis and translation under biotic and abiotic stresses.Nature communications · 2025Article
- LRR-RLK subfamily II of coreceptors: emerging, non-canonical and canonical roles in plant antiviral immunity and development.Frontiers in plant science · 2025Review
- Review
- Review
- Influence of virus-host interactions on plant response to abiotic stress.Plant cell reports · 2021Review
- Proteome Mapping of South African Cassava Mosaic Virus-Infected Susceptible and Tolerant Landraces of Cassava.Proteomes · 2021Article
- The Association between New World Alphasatellites and Bipartite Begomoviruses: Effects on Infection and Vector Transmission.Pathogens (Basel, Switzerland) · 2021Article
- Geminivirus-Host Interactions: Action and Reaction in Receptor-Mediated Antiviral Immunity.Viruses · 2021Review
- Geminiviral Triggers and Suppressors of Plant Antiviral Immunity.Microorganisms · 2021Review
- Translational gene regulation in plants: A green new deal.Wiley interdisciplinary reviews. RNA · 2020Review
- Molecular insight into cotton leaf curl geminivirus disease resistance in cultivated cotton (Gossypium hirsutum).Plant biotechnology journal · 2020Article
- A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions.Frontiers in plant science · 2020Review
- Geminivirus Resistance: A Minireview.Frontiers in plant science · 2020Review
- The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.Nature communications · 2019Article
- Virus perception at the cell surface: revisiting the roles of receptor-like kinases as viral pattern recognition receptors.Molecular plant pathology · 2019Review
- Perception of double-stranded RNA in plant antiviral immunity.Molecular plant pathology · 2019Review
- Exploring the Diversity of Mechanisms Associated With Plant Tolerance to Virus Infection.Frontiers in plant science · 2018Review
- Resistance to tomato leaf curl New Delhi virus in melon is controlled by a major QTL located in chromosome 11.Plant cell reports · 2017Article
- Tomato leaf curl New Delhi virus: a widespread bipartite begomovirus in the territory of monopartite begomoviruses.Molecular plant pathology · 2017Review
- Geminivirus data warehouse: a database enriched with machine learning approaches.BMC bioinformatics · 2017Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Begomovirus-associated epidemics currently threaten tomato production worldwide due to the emergence of highly pathogenic virus species and the proliferation of a whitefly B biotype vector that is adapted to tomato. To generate an efficient defence against begomovirus, we modulated the activity of the immune defence receptor nuclear shuttle protein (NSP)-interacting kinase (NIK) in tomato plants; NIK is a virulence target of the begomovirus NSP during infection. Mutation of T474 within the kinase activation loop promoted the constitutive activation of NIK-mediated defences, resulting in the down-regulation of translation-related genes and the suppression of global translation. Consistent with these findings, transgenic lines harbouring an activating mutation (T474D) were tolerant to the tomato-infecting begomoviruses ToYSV and ToSRV. This phenotype was associated with reduced loading of coat protein viral mRNA in actively translating polysomes, lower infection efficiency and reduced accumulation of viral DNA in systemic leaves. Our results also add some relevant insights into the mechanism underlying the NIK-mediated defence. We observed that the mock-inoculated T474D-overexpressing lines showed a constitutively infected wild-type transcriptome, indicating that the activation of the NIK-mediated signalling pathway triggers a typical response to begomovirus infection. In addition, the gain-of-function mutant T474D could sustain an activated NIK-mediated antiviral response in the absence of the virus, further confirming that phosphorylation of Thr-474 is the crucial event that leads to the activation of the kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.