Evidence map›Paper›PMID 25688369›Full record

ArticleBioMed research international2015

Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.

Yang Chen, Tao Sun, Junzhen Wu, Bill Kalionis, Changcheng Zhang, Ding Yuan, Jianhua Huang, Waijiao Cai, Hong Fang, Shijin Xia

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Icariin Improves Stress Resistance and Extends Lifespan inInternational journal of molecular sciences · 2023
    Article
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  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Yang ChenCenter of Disease Prevention and Treatment, Shanghai Guanghua Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai 200052, China.
Tao SunDepartment of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
Junzhen WuDepartment of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
Bill KalionisDepartment of Perinatal Medicine, Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, VIC 3052, Australia.
Changcheng ZhangMedical College, China Three Gorges University, Yichang 443002, China.
Ding YuanMedical College, China Three Gorges University, Yichang 443002, China.
Jianhua HuangKey Laboratory of Cellular and Molecular Biology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Waijiao CaiKey Laboratory of Cellular and Molecular Biology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Hong FangDepartment of Diseases Prevention and Healthcare, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Shijin XiaDepartment of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
China Three Gorges University · CNHuadong Hospital · CNHuashan Hospital · CNFudan University · CNLonghua Hospital Shanghai University of Traditional Chinese Medicine · CNShanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine · CNUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-κB pathway. Investigating the effect of ICA on the enzymatic activity of histone deacetylase SIRT6 revealed a concentration of 10(-8) mol/L ICA had a maximum activating effect on histone deacetylase SIRT6 enzymatic activity. Western analysis showed that ICA upregulated SIRT6 protein expression and downregulated NF-κB (p65) protein expression in animal tissues and cell models. ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-κB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-κB downstream target genes TNF-α, ICAM-1, IL-2, and IL-6. Those effects were mediated directly or indirectly by SIRT6. We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF-κB (a regulator of inflammation).

Indexed as

Analysis of VarianceAnimalsCardiovascular AgentsCells, CulturedCellular SenescenceDrugs, Chinese HerbalEndothelial CellsFlavonoidsGene ExpressionMaleMiceMice, Inbred BALB CNF-kappa BSignal TransductionSirtuinsCardiovascular AgentsDrugs, Chinese HerbalFlavonoidsicariinNF-kappa BSirt6 protein, mouseSirtuins

Identifiers

PMID25688369
PMCPMC4320867
OpenAlexW2079922753

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.