Evidence map›Paper›PMID 25688361›Full record

ReviewBioMed research international2015

Dietary factors in the etiology of Parkinson's disease.

Zeynep S Agim, Jason R Cannon

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Adherence toFrontiers in nutrition · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Common and Trace Metals in Alzheimer's and Parkinson's Diseases.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
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  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zeynep S AgimSchool of Health Sciences, Purdue University, 550 Stadium Mall Dr., West Lafayette, IN 47907, USA.
Jason R CannonSchool of Health Sciences, Purdue University, 550 Stadium Mall Dr., West Lafayette, IN 47907, USA.
Purdue University West Lafayette · US

Funding

New Approaches to Gene-environment Interaction Modeling in Parkinson's DiseaseR00ES019879 · NIEHS · PURDUE UNIVERSITY · PI CANNON, JASON R · 2012 to 2014
$747k
PhIP-induced neurodegeneration: mechanisms and relevance to Parkinson's diseaseR03ES022819 · NIEHS · PURDUE UNIVERSITY · PI CANNON, JASON R · 2014 to 2015
$154k
NIEHS NIH HHS R00 ES019879NIEHS NIH HHS R00ES019879NIEHS NIH HHS R03 ES022819NIEHS NIH HHS R03ES022819
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The majority of cases do not arise from purely genetic factors, implicating an important role of environmental factors in disease pathogenesis. Well-established environmental toxins important in PD include pesticides, herbicides, and heavy metals. However, many toxicants linked to PD and used in animal models are rarely encountered. In this context, other factors such as dietary components may represent daily exposures and have gained attention as disease modifiers. Several in vitro, in vivo, and human epidemiological studies have found a variety of dietary factors that modify PD risk. Here, we critically review findings on association between dietary factors, including vitamins, flavonoids, calorie intake, caffeine, alcohol, and metals consumed via food and fatty acids and PD. We have also discussed key data on heterocyclic amines that are produced in high-temperature cooked meat, which is a new emerging field in the assessment of dietary factors in neurological diseases. While more research is clearly needed, significant evidence exists that specific dietary factors can modify PD risk.

Indexed as

DietEnvironmental ExposureAlcoholsAnimalsDisease Models, AnimalFlavonoidsHumansMetals, HeavyMiceParkinson DiseasePesticidesVitaminsAlcoholsFlavonoidsMetals, HeavyPesticidesVitamins

Identifiers

PMID25688361
PMCPMC4320877
OpenAlexW1972845766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.